The oral susceptibility of South African field populations of Culicoides to African horse sickness virus

Medical and Veterinary Entomology
G J VenterJ T Paweska

Abstract

Twenty-two isolates of African horse sickness virus (AHSV), representing its distinct serotypes, geographical and historical origins, were fed to three populations of South African livestock-associated Culicoides spp. (Diptera, Ceratopogonidae). Infective blood meals included 12 recent isolates, nine historical reference strains and one live attenuated vaccine strain serotype 7 (AHSV-7) of the virus. Field-collected midges were fed through a chicken-skin membrane on sheep blood spiked with one of the viruses, which concentrations ranged from 5.4 to 8.8 log(10)TCID(50)/mL of blood. After 10 days incubation at 23.5 degrees C, AHSV was isolated from 11 Culicoides species. Standard in vitro passaging of AHSV-7, used for the preparation of live attenuated vaccine, did not reduce its ability to infect Culicoides species. Virus recovery rates in orally infected Culicoides midges differed significantly between species and populations, serotypes, isolates and seasons. Significant variations in oral susceptibility recorded in this study emphasize a complex inter-relationship between virus and vector, which is further influenced by multiple intrinsic and extrinsic factors. As it is not possible to standardize all these factors under labor...Continue Reading

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Citations

May 18, 2012·Journal of Virology·Violeta ManoleSarah J Butcher
Dec 26, 2015·Parasites & Vectors·Maria G OnyangoJean-Bernard Duchemin
Aug 6, 2015·The Onderstepoort Journal of Veterinary Research·Stuart J G GordonChris Hamblin
May 28, 2016·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Tania de WaalHuib van Hamburg
Feb 1, 2017·Annual Review of Entomology·Simon CarpenterGert J Venter
Dec 3, 2016·Journal of Virology·René G P van GennipPiet A van Rijn
Mar 8, 2017·EFSA Journal·UNKNOWN EFSA Panel on Animal Health and Welfare

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