The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6J mice

The Journal of Pharmacy and Pharmacology
Xiao-Hong ChenRong-Biao Pi

Abstract

This study aimed to investigate the possible modification of the neuroprotective effect of sodium ferulate, when orally co-administered with borneol, in transient global cerebral ischaemia-induced functional, histological and cellular alterations in mice. The bilateral common carotid artery occlusion was conducted in C57 BL/6J mice for 25 min. The mice were then subjected to a water maze test over an extended recovery period, followed by an assessment of neuronal loss in the CA1 region of the hippocampus (haematoxylin and eosin staining). The blood-brain barrier permeability (Evans blue tracing), brain oedema and oxidative stress were assayed and histological sections were also immunostained for gliofibrillar acid protein (GFAP) expression. The ischaemia reperfused mice were associated with long-lasting spatial learning deficits in the absence of other behavioural impairments and with neurodegeneration in the hippocampal CA1 region. However, the histological injuries were significantly attenuated by oral co-administration of sodium ferulate and borneol. Furthermore, combined treatment with sodium ferulate and borneol resulted in a significant reduction in brain oedema, GFAP-positive cells, malonaldialdehyde levels and blood-bra...Continue Reading

References

Mar 1, 1983·Journal of Agricultural and Food Chemistry·A C Eldridge, W F Kwolek
Feb 14, 1998·Phytochemistry·W M Keung, B L Vallee
Oct 9, 2002·Journal of Pharmaceutical and Biomedical Analysis·Bing-Sheng YuYan-Pin Rao
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
Apr 3, 2003·Journal of Agricultural and Food Chemistry·Stephen M BouéThomas E Cleveland
Apr 29, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Yan ZhangXinmiao Liang
Jul 6, 2005·Biological & Pharmaceutical Bulletin·Kyoung Ah KangJin Won Hyun
May 30, 2006·Journal of Ethnopharmacology·Suchinda MalaivijitnondWichai Cherdshewasart
Aug 4, 2006·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·David M PenetarScott E Lukas
Aug 26, 2006·Journal of Pharmaceutical and Biomedical Analysis·Wichai CherdshewasartWinai Dahlan
Jan 27, 2007·Planta medica·H RongD D Keukeleire
Feb 24, 2007·Neuroscience Letters·Youngmin BuHocheol Kim
May 16, 2007·Phytochemical Analysis : PCA·Chen SibaoAlbert S C Chan
Mar 7, 2008·Journal of Ethnopharmacology·Fang-Pey ChenShinn-Jang Hwang

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