The Organization of Controller Motifs Leading to Robust Plant Iron Homeostasis

PloS One
Oleg AgafonovPeter Ruoff

Abstract

Iron is an essential element needed by all organisms for growth and development. Because iron becomes toxic at higher concentrations iron is under homeostatic control. Plants face also the problem that iron in the soil is tightly bound to oxygen and difficult to access. Plants have therefore developed special mechanisms for iron uptake and regulation. During the last years key components of plant iron regulation have been identified. How these components integrate and maintain robust iron homeostasis is presently not well understood. Here we use a computational approach to identify mechanisms for robust iron homeostasis in non-graminaceous plants. In comparison with experimental results certain control arrangements can be eliminated, among them that iron homeostasis is solely based on an iron-dependent degradation of the transporter IRT1. Recent IRT1 overexpression experiments suggested that IRT1-degradation is iron-independent. This suggestion appears to be misleading. We show that iron signaling pathways under IRT1 overexpression conditions become saturated, leading to a breakdown in iron regulation and to the observed iron-independent degradation of IRT1. A model, which complies with experimental data places the regulation o...Continue Reading

References

May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D EideM L Guerinot
Aug 26, 1998·Annual Review of Nutrition·D J Eide
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·H Q LingM W Ganal
Jul 8, 1999·Plant Molecular Biology·Y O KorshunovaH B Pakrasi
Apr 5, 2000·Biochimica Et Biophysica Acta·M L Guerinot
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·T M YiJ Doyle
Jan 12, 2002·Journal of Theoretical Biology·H El-SamadM Khammash
Feb 6, 2003·Planta·Rüdiger Hell, Udo W Stephan
Jan 1, 1964·The Journal of Surgical Research·R C DOBERNECK, B ZIMMERMANN
Sep 27, 2003·Annual Review of Plant Biology·Catherine Curie, Jean-François Briat
Mar 24, 2004·Neuroscience and Biobehavioral Reviews·M A MorganD W Pfaff
Nov 13, 2004·The Plant Cell·Elizabeth P Colangelo, Mary Lou Guerinot
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Guy ShinarUri Alon
Dec 8, 2006·Molecular & Cellular Proteomics : MCP·Michel JaquinodJacques Bourguignon
Apr 17, 2007·Current Opinion in Plant Biology·Jean-François BriatFrédéric Gaymard
May 1, 2007·Plant Physiology and Biochemistry : PPB·Petra BauerMary Lou Guerinot
May 9, 2007·FEBS Letters·Sun A Kim, Mary Lou Guerinot
Aug 8, 2007·The Journal of Biological Chemistry·Arvinder SinghDaniel J Kosman
Aug 30, 2008·Current Opinion in Plant Biology·Elsbeth L Walker, Erin L Connolly
Oct 2, 2008·The Plant Journal : for Cell and Molecular Biology·Karl RavetFrançoise Cellier
Apr 21, 2009·Trends in Plant Science·Jeeyon Jeong, Mary Lou Guerinot
Jul 10, 2009·Journal of the Royal Society, Interface·Marion Jasnin
Oct 16, 2009·The Journal of Biological Chemistry·Céline DucFrédéric Gaymard
Dec 23, 2009·Biochimica Et Biophysica Acta·Jean-François BriatFrédéric Gaymard
Mar 4, 2010·Biophysical Journal·Ingunn W JolmaPeter Ruoff
Oct 6, 2010·Plant Physiology·Rick AmasinoDon Ort
Mar 24, 2011·The Plant Journal : for Cell and Molecular Biology·Alicia SivitzGrégory Vert
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marie BarberonGrégory Vert

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Citations

Aug 25, 2016·Biopolymers·Nicolau Brito da CunhaSimoni Campos Dias
Jun 3, 2017·The Journal of Physical Chemistry. B·Gunhild FjeldPeter Ruoff
Mar 15, 2019·BMC Systems Biology·J Krishnan, Ioannis Floros

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Methods Mentioned

BETA
isothermal titration calorimetry
dot blots

Software Mentioned

LSODE
gnuplot
Matlab
Adobe Illustrator

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