The organization of hypothalamocerebellar cortical fibers in the squirrel monkey (Saimiri sciureus)

The Journal of Comparative Neurology
D E HainesT E Sowa

Abstract

The organization and distribution of hypothalamocerebellar cortical fibers in squirrel monkey were investigated by using horseradish peroxidase (HRP, WGA-HRP) and 3H-leucine as anterograde tracers. Following hypothalamic injections, anterogradely labeled fibers coursed bilaterally through the periventricular gray (ipsilateral preponderance) and into the cerebellar white matter. Sparse numbers of labeled fibers appeared to descend into the reticular formation and enter the cerebellum via the brachium pontis. The pattern of cerebellar cortical labeling does not conform to that of mossy or climbing fibers. Labeled axons enter and branch within the granular layer, proceed around Purkinje cell somata, and enter the molecular layer. Within the latter some labeled fibers branch outwardly in a fanlike manner whereas others ascend before branching. Many fibers within the molecular layer ultimately assume an orientation that is similar to that of parallel fibers. The distribution patterns of hypothalamocerebellar cortical axons resemble those reported for monoaminergic fibers in the cerebellar cortex. Afferent fibers to the cerebellar cortex (including hypothalamocerebellar) that do not terminate as mossy or climbing fibers may collectiv...Continue Reading

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