Jan 1, 1986

The organization of serotonin-immunoreactive neuronal systems in the brain of the crested newt, Triturus cristatus carnifex Laur

Cell and Tissue Research
A FasoloH W Steinbusch

Abstract

The distribution of serotonin (5-HT) immunoreactive structures has been investigated in the brain of the crested newt by means of indirect immunofluorescence, and unlabeled antibody peroxidase-antiperoxidase-complex (PAP) or biotin-avidin-system (BAS) techniques. In the newt, the bulk of the serotoninergic system extends from the raphe region of the medulla oblongata, through the isthmus, toward the mesencephalic tegmentum, and is characterized by pyriform neurons mainly located in a subependymal position, close to the midline. Also in the caudal hypothalamus, in addition to some 5-HT-positive adenohypophysial cells, many immunoreactive CSF-contacting neurons are found lining the paraventricular organ and the nucleus infundibularis dorsalis. A rich serotoninergic innervation was observed in the preoptic area and in the habenular complex. Concerning the telencephalon, immunopositive nerve fibers are encountered in the dorsal pallium, primordium hippocampi, striatum and olfactory bulbs. The general organization of serotoninergic systems in the newt brain exhibit close similarities to that described in higher vertebrates.

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Mentioned in this Paper

Vertebrates
Immunofluorescence Assay
Newts
Neostriatum
Structure of Olfactory Bulb
Entire Pallium
Serotonin Measurement
Entire Medulla Oblongata
Muscle Innervation, Function
Neurons

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