PMID: 9188806May 22, 1997Paper

The organochlorine pesticide heptachlor disrupts the structure of model and cell membranes

Biochimica Et Biophysica Acta
M SuwalskyC P Sotomayor

Abstract

Heptachlor is an organochlorine pesticide which is particularly toxic for aquatic life. A significant source of this pesticide for infants is breast milk, where its concentration is considerably higher than in dairy milk. Given the lipophilic character of heptachlor, lipid-rich cell membranes are a very plausible target for its interaction with living organisms. In order to evaluate its toxicity towards cell membranes, heptachlor was made to interact with human erythrocytes and molecular models of the red cell membrane. These consisted of multilayers of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), which are types of phospholipids that are respectively located in the outer and inner monolayers of the erythrocyte membrane, and large unilamellar vesicles (LUV) of DMPC. Observations by scanning electron microscopy showed that 10 mM heptachlor produced various degrees of shape alterations to erythrocytes, which ranged from a few blebs in some cells to a great number of protuberances in others. On the other hand, experiments performed by X-ray diffraction on DMPC and DMPE indicated that the bilayer structure of DMPC was much more affected by heptachlor than that of DMPE. Measurements by fluore...Continue Reading

References

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Citations

Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SuwalskyC P Sotomayor
Jul 27, 2001·Brain Research Bulletin·M SuwalskyP Zatta
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M SuwalskyL Quevedo
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M SuwalskyP Sotomayor
Apr 3, 1999·Toxicology and Industrial Health·I VocciaM Fournier
May 14, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K PrasanthiP S Rajini
Mar 30, 2017·The Journal of Physical Chemistry. B·Christine A GobroggeRobert A Walker
Dec 1, 2018·The Journal of Physical Chemistry. B·Aneta WojcikMarcin Broniatowski

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