PMID: 7546206Sep 1, 1995Paper

The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity

Immunology Today
R C Budd, P F Mixter

Abstract

Ralph Budd and Philip Mixter present a hypothesis suggesting that CD4-CD8-TCR alpha beta+ cells arising in the normal thymus result from a high-avidity T-cell receptor (TCR) signal bordering on negative selection. In normal mice, this subset is likely to be gradually deleted but, in the absence of Fas, these cells persist in lpr mice. The model they describe makes several predictions regarding the nature of this unusual T-cell subset.

References

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Citations

May 23, 2001·International Immunopharmacology·G LeposavićB Vidić-Danković
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·K NakagawaK Onoé
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·C IwabuchiK Onoé
Sep 22, 1998·The Journal of Experimental Medicine·J Q RussellR C Budd
Jul 20, 2005·The Journal of Experimental Medicine·Siobhán C CowleyKaren L Elkins
Mar 6, 2010·International Immunology·T Kent TeagueC Justin Van De Wiele
Nov 1, 1996·American Journal of Reproductive Immunology : AJRI·A G RijhsinghaniT J Waldschmidt
Apr 5, 1997·Annals of the New York Academy of Sciences·S L Peng, J Craft
Mar 24, 2005·Neuroimmunomodulation·Gordana LeposavićDusko Kosec
Mar 30, 2007·Regulatory Peptides·Danica M Petrović-DjergovićMićić V Mileva
Mar 15, 2005·International Reviews of Immunology·Aiden C J MarshallBan-Hock Toh
Mar 15, 2005·The International Journal of Neuroscience·Dusko KosecGordana Leposavić
Feb 9, 2000·Rheumatology·M L Stoll, J Gavalchin
Jun 24, 2009·Experimental Biology and Medicine·Zorica Stojić-VukanićGordana Leposavić
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda A TrimbleHarvey Cantor
Apr 6, 2005·The International Journal of Neuroscience·Dusko KosecGordana Leposavić
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P E LoveE W Shores
Jul 17, 1998·Cellular Immunology·M D MannieP Y Arnold
Feb 16, 2005·Journal of Neuroimmunology·Irena P ZivkovićMileva V Mićić

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