The origin of cerebrospinal fluid somatostatin: hypothalamic or disperse central nervous system secretion?

Neuroendocrinology
K V SørensenH Orskov

Abstract

The present study deals with the origin of somatostatin in cerebrospinal fluid. Two groups of experiments were performed: (1) Diagnostic lumbar puncture was performed in 37 patients admitted for various neurological diseases. Immunological determination of albumin and gamma-globulin, and radioimmunological analysis of somatostatin in successive cerebrospinal fluid taps demonstrated that while the protein concentration was approximately 20% lower in the 11th ml compared to the 1st ml drawn, the somatostatin concentration was constant. (2) Intravenous arginine infusion (30 G/30 min) induced identical patterns of plasma growth hormone in 8 patients with multiple sclerosis in relapse, in 6 patients with multiple sclerosis in the stable phase, and in 7 patients in whom no neurological disease was eventually diagnosed. Cerebrospinal fluid somatostatin was significantly lower in the patients with multiple sclerosis in relapse than in the two other groups, while cerebrospinal fluid growth hormone concentration was identical. There was no correlation between basal or arginine provoked plasma growth hormone and the cerebrospinal fluid content of somatostatin. The results indicate that cerebrospinal fluid somatostatin is released disperse...Continue Reading

Citations

Oct 1, 1990·Annals of Neurology·E MatsubaraK Wakabayashi
Jan 1, 1985·Psychopharmacology·D R RubinowS Reichlin
Aug 1, 1986·Biological Psychiatry·M SerbyJ P Rotrosen
Nov 1, 1985·Journal of the Neurological Sciences·M F BealJ B Martin
Nov 8, 1982·Life Sciences·P L WoodN P Nair
Jan 1, 1992·Life Sciences·G Bissette, B Myers
Sep 1, 1990·Psychiatry Research·M J KruesiJ L Rapoport
Jan 1, 1984·Peptides·S M SagarJ B Martin
Sep 1, 1986·Neurobiology of Aging·E HollanderK L Davis
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R RubinowJ C Ballenger
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·M F Beal, J H Growdon
Jan 1, 1984·Psychoneuroendocrinology·H Agren, G Lundqvist
Apr 30, 1983·Lancet·K S ChannerG Walters
Aug 1, 1989·Psychological Medicine·H KoponenP J Riekkinen
Mar 1, 1993·The Japanese Journal of Psychiatry and Neurology·M YasudaK Maeda
Oct 1, 1985·Journal of the American Geriatrics Society·O J ThienhausH B Bosmann
Mar 1, 1989·Pharmacology & Toxicology·A PitkänenP Riekkinen
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·A Gjerris
Mar 1, 1987·Acta Neurologica Scandinavica·K V Sørensen
Dec 17, 2020·Nature Reviews. Drug Discovery·Dennis S W LeeJennifer L Gommerman
Apr 1, 1986·Biological Psychiatry·D R Rubinow
Nov 1, 1986·Annals of Neurology·M F Beal, J B Martin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.