The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation

The Journal of Comparative Neurology
A I Basbaum, H L Fields

Abstract

There is considerable evidence that the dorsolateral funiculus (DLF) of the spinal cord contains descending pathways critical for both opiate and brainstem stimulation-produced analgesia. To obtain a comprehensive map of brainstem neurons projecting to the spinal cord via the DLF, large injections of horseradish peroxidase (HRP) were made into the lumbosacral spinal cord of cat and rat. These injections were made caudal to midthoracic lesions which spared only a single DLF or ventral quadrant (VQ); thus only those neurons whose axons descended in the spared funiculus would be labelled. Cells with descending axons in the VQ were concentrated in the medullary nucleus raphe pallidus and obscurus, nucleus retroambiguus and in various subregions of the reticular formation including the nucleus reticularis ventralis, gigantocellularis, magnocellularis, pontis caudalis and pontis oralis. Significant numbers of neurons were also found in medial and lateral vestibular nuclei and in several presumed catecholamine-containing neurons of the dorsolateral pons. In the rat, but not in the cat, considerable numbers of cells are present in the mesencephalic reticular formation just lateral to the periaqueductal gray. In both species, some cells...Continue Reading

References

Feb 21, 1977·European Journal of Pharmacology·T L YakshT A Rudy
Nov 26, 1976·Brain Research·C B SaperW M Cowan
Jun 15, 1977·The Journal of Comparative Neurology·H Burton, A D Loewy
Aug 29, 1975·Brain Research·H Akil, J C Liebeskind
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SimantovS H Snyder
Dec 1, 1976·Pain·D J Mayer, D D Price
Jan 1, 1978·Annual Review of Physiology·H L Fields, A I Basbaum
Nov 1, 1978·Annals of Neurology·A I Basbaum, H L Fields
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
Nov 4, 1977·Brain Research·H G Kuypers, V A Maisky
Sep 15, 1978·The Journal of Comparative Neurology·A D Loewy, H Burton
May 13, 1977·Brain Research·H L FieldsS D Anderson
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A I BasbaumH L Fields
Nov 21, 1975·Brain Research·H K Proudfit, E G Anderson
Jan 1, 1968·The Journal of Physiology·I EngbergR W Ryall
Sep 1, 1974·The Journal of Comparative Neurology·B E Jones, R Y Moore
Mar 1, 1970·Journal of Neurophysiology·B N Christensen, E R Perl
Jan 1, 1970·Experimental Brain Research·B V Clineschmidt, E G Anderson
May 1, 1957·The Anatomical Record·A TORVIK, A BRODAL
Jan 1, 1964·Acta Physiologica Scandinavica·A CARLSSONN A HILLARP

❮ Previous
Next ❯

Citations

Jan 1, 1988·Experimental Brain Research·P MasonR Maciewicz
Jan 1, 1983·Anatomy and Embryology·H J ten DonkelaarR de Boer-van Huizen
Jan 1, 1984·Anatomy and Embryology·M Björkeland, J Boivie
Sep 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu D IgnatovN V Petriaevskaia
Jan 1, 1990·Neir̆ofiziologiia = Neurophysiology·E V AbzianidzeL A Begeladze
Oct 12, 2010·Brain Structure & Function·Huazheng LiangCharles Watson
Jul 8, 2011·Brain Structure & Function·Huazheng LiangCharles Watson
Oct 12, 2012·Brain Structure & Function·Huazheng LiangGeorge Paxinos
Dec 17, 2009·Journal of Neural Transmission·Ana C BarcelóJorge Horacio Pazo
Jul 27, 2011·Cellular and Molecular Neurobiology·Ana C BarcelóJorge H Pazo
May 16, 1983·Brain Research·S G HardyG R Leichnetz
Dec 9, 1985·Brain Research·C A Livingston, R B Leonard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.