PMID: 9166315May 1, 1997Paper

The origin of endothelin-1 in patients with severe preeclampsia

Obstetrics and Gynecology
O A RustJ N Martin

Abstract

To determine the site of origin of increased concentrations of plasma endothelin-1 in patients with severe preeclampsia. Twelve patients with severe preeclampsia undergoing an indicated abdominal delivery had endothelin-1 levels measured from plasma specimens drawn from right and left uterine and antecubital veins before delivery and after placenta removal with uterine curettage. Twelve uncomplicated control patients undergoing abdominal delivery had endothelin-1 concentrations drawn by an identical protocol. Clinical staff members were blinded to endothelin-1 results and laboratory staff were blinded to patient group assignment and sample source. Endothelin-1 plasma concentrations were determined by radioimmunoassay and data were analyzed by paired t test. No difference in endothelin-1 concentration was noted with respect to placental location, central versus peripheral, or predelivery versus postdelivery sampling procedures. Overall, patients with preeclampsia had higher plasma concentrations of endothelin-1 (mean 11.0 +/- 6.6 pg/mL) compared with normotensive patients (mean 8.4 +/- 6.7 pg/mL, P < .005). The decidual-placental interface does not appear to be the source of increased plasma endothelin-1 concentrations found in ...Continue Reading

References

Mar 1, 1992·American Journal of Obstetrics and Gynecology·B A ClarkF H Epstein
Jan 31, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G G ZeemanA A Kraayenbrink
Jul 25, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G A DekkerG J van Kamp
Sep 1, 1991·American Journal of Obstetrics and Gynecology·A NovaM D Mitchell
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R N TaylorJ M Roberts
Dec 1, 1990·Circulation·K B MarguliesJ C Burnett

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Citations

Oct 2, 2002·Clinical Endocrinology·Nigel M Page
Nov 19, 2003·American Journal of Therapeutics·Freddy ContrerasManuel Velasco
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nonna MakkonenPertti Kirkinen
Dec 26, 2002·American Journal of Obstetrics and Gynecology·Gerard Celia, George Osol
Aug 17, 2000·Nitric Oxide : Biology and Chemistry·D T Lowe
Nov 23, 2006·Medical Hypotheses·Lucijan Mohorovic
May 4, 2004·Obstetrics and Gynecology·Mette Ree HoltheTorstein Lyberg
Feb 21, 2002·Critical Care Nursing Quarterly·A D Angerio
Oct 9, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frank T SpradleyJoey P Granger
Jan 9, 2019·Frontiers in Physiology·Patricio Lopez-JaramilloCamilo Felix
Oct 5, 2006·Annals of Saudi Medicine·Enyioma ObinecheMichael P T Gillett
Aug 8, 2021·Journal of Clinical Medicine·Natalie K BinderNatalie J Hannan

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