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The origin of MHC class II gene polymorphism within the genus Mus

Nature

Apr 14, 1988

Thomas J McConnellEdward K. Wakeland

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Abstract

The I region of the major histocompatibility complex (MHC) of the mouse (H-2) contains a tightly-linked cluster of highly polymorphic genes (class II MHC genes) which control immune responsiveness. Speculation on the origin of this polymorphism, which is believed to be essential for the...read more

Mentioned in this Paper

Molecular Analysis
Short Interspersed Nucleotide Elements
Genetic Polymorphism
Restriction Site
H-2 Antigens
Mus
Genes, MHC Class II
Introns
Base Sequence
Mini-Exon
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  • The origin of MHC class II gene polymorphism within the genus Mus

    Nature

    Apr 14, 1988

    Thomas J McConnellEdward K. Wakeland

    PMID: 2895893

    DOI: 10.1038/332651a0

    Abstract

    The I region of the major histocompatibility complex (MHC) of the mouse (H-2) contains a tightly-linked cluster of highly polymorphic genes (class II MHC genes) which control immune responsiveness. Speculation on the origin of this polymorphism, which is believed to be essential for the...read more

    Mentioned in this Paper

    Molecular Analysis
    Short Interspersed Nucleotide Elements
    Genetic Polymorphism
    Restriction Site
    H-2 Antigens

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    • Citations47

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