The origin of polynucleotide-directed protein synthesis.

Journal of Molecular Evolution
L E Orgel

Abstract

If protein synthesis evolved in an RNA world it was probably preceded by simpler processes by means of which interaction with amino acids conferred selective advantage on replicating RNA molecules. It is suggested that, at first, the simple attachment of amino acids to the 2'(3')-termini of RNA templates favored initiation of replication at the end of the template rather than at internal positions. The second stage in the evolution of protein synthesis would probably have been the association of pairs of charged RNA adaptors in such a way as to favor noncoded formation of peptides. Only after this process had become efficient could coded synthesis have begun.

References

Dec 29, 1975·Journal of Molecular Evolution·A L Weber, J C Lacey
May 12, 1978·Journal of Molecular Evolution·A L Weber, L E Orgel
Aug 2, 1978·Journal of Molecular Evolution·A L Weber, L E Orgel
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·U Lagerkvist
Oct 1, 1979·Journal of Molecular Evolution·A L Weber, L E Orgel
Dec 1, 1976·Origins of Life·F H CrickG Pieczenik
Mar 29, 1976·Journal of Molecular Evolution·H B White
Sep 1, 1985·Cell·P A Sharp
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·S A BennerJ A Piccirilli
Nov 21, 1988·Journal of Theoretical Biology·N Lehman, T H Jukes
Jan 1, 1987·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·A MarJ Oró
Jan 1, 1987·Journal of Molecular Evolution·A L Weber
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D G Jay, W Gilbert
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A M Weiner, N Maizels
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T SamuelssonU Lagerkvist
Sep 20, 1987·Journal of Molecular Biology·O L Acevedo, L E Orgel
Oct 11, 1972·Biochimica Et Biophysica Acta·D HentzenJ P Garel
Aug 24, 1973·Biochimica Et Biophysica Acta·A L Weber, S W Fox
Dec 1, 1968·Journal of Molecular Biology·F H Crick
Jan 1, 1965·Progress in Nucleic Acid Research and Molecular Biology·H G Zachau, H Feldmann
Dec 1, 1968·Journal of Molecular Biology·L E Orgel
Jan 1, 1984·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·D A Usher, M C Needels
Jan 1, 1984·Journal of the American Chemical Society·A T Profy, D A Usher

❮ Previous
Next ❯

Citations

Dec 1, 1993·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·N Lahav
Dec 1, 1993·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·J I ManchesterR Rein
Dec 1, 1996·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·M Di Giulio
Jan 1, 1991·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·J T Wong
May 1, 1993·Journal of Molecular Evolution·J KonecnyG L Hofacker
Jun 27, 2007·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Peter Strazewski
Sep 21, 2007·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Alexander V Yakhnin
Sep 3, 2010·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Maya Fishkis
Nov 26, 2003·Journal of Theoretical Biology·Massimo Di Giulio
Jun 4, 1999·Trends in Genetics : TIG·E Szathmáry
Jan 19, 2000·Trends in Genetics : TIG·I Szathmáry
May 1, 1995·Trends in Ecology & Evolution·E Jablonka, E Szathmáry
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·D A SarracinoC Richert
Jun 1, 1997·Bioorganic & Medicinal Chemistry·B S Henderson, P Schimmel
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E Szathmáry
Mar 7, 2009·Nucleic Acids Research·Norimasa KashiwagiYoshiya Ikawa
Jan 29, 2011·Journal of Virology·Clémentine Delan-ForinoClaire Torchet
Mar 5, 2009·Microbiology and Molecular Biology Reviews : MMBR·John F Atkins, Glenn R Björk
May 30, 2009·PloS One·Pavel V BaranovGregory Provan
Sep 29, 2011·PloS One·Chengguo YaoUlrich F Müller
Sep 4, 2012·Trends in Biochemical Sciences·Isabella Moll, Hanna Engelberg-Kulka
Dec 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anton S PetrovLoren Dean Williams
Oct 23, 2013·Journal of Molecular Evolution·David W Morgens
Mar 5, 2015·Annals of the New York Academy of Sciences·Ádám KunEörs Szathmáry
Aug 21, 1991·Journal of Theoretical Biology·N Lahav
Dec 22, 2016·Angewandte Chemie·Helmut GriesserClemens Richert
Dec 22, 2016·Angewandte Chemie·Helmut GriesserClemens Richert
Jun 10, 2018·Rapid Communications in Mass Spectrometry : RCM·Sloane L English, Jay G Forsythe
Apr 20, 2007·Chemistry & Biodiversity·Jacques Ninio
Jul 12, 2002·Nature·Gerald F Joyce
Dec 7, 2019·Physical Chemistry Chemical Physics : PCCP·Yi SunMartha A Grover
May 7, 2020·Chemical Reviews·Jessica C BowmanLoren Dean Williams
Aug 31, 2002·Journal of Theoretical Biology·David S Stevenson
Jun 8, 2021·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Juan A Martínez-Giménez, Rafael Tabares-Seisdedos
Jul 28, 2021·Nature Chemistry·Ya Ying Zheng, Jia Sheng
Jul 28, 2021·Nature Chemistry·Biswarup JashClemens Richert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
J T Wong
Proceedings of the National Academy of Sciences of the United States of America
P Schimmel, B Henderson
© 2022 Meta ULC. All rights reserved