The Origin of Skin Dendritic Cell Network and Its Role in Psoriasis

International Journal of Molecular Sciences
Tae-Gyun KimMin-Geol Lee

Abstract

Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DCs usually denotes conventional DCs (cDCs). Skin contains a unique DC network mainly composed of embryo precursor-derived epidermal Langerhans cells (LCs) and bone marrow-derived dermal cDCs, which can be further classified into type 1 (cDC1) and type 2 (cDC2) subsets. Psoriasis is a chronic inflammatory skin disease, which is principally mediated by IL-23/IL-17 cytokine axis. In the psoriatic skins, DCs are prominent cellular sources for TNF-α and IL-23, and the use of blocking antibodies against TNF-α and IL-23 leads to a significant clinical improvement in psoriatic patients. Recent elegant human and mouse studies have shown that inflammation-induced inflammatory DCs, LCs, dermal cDC2, and monocyte-derived DCs are pivotal DC subsets in psoriatic inflammation. Thus, targeting specific pathogenic DC subsets would be a potential strategy for alleviating and preventing DC-derived IL-23-dependent psoriatic inflammatio...Continue Reading

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Citations

Feb 10, 2018·International Journal of Molecular Sciences·Marie-Astrid BoutetCostantino Pitzalis
Jun 4, 2019·Experimental Dermatology·Indra N DahmkeMatthias W Laschke
Dec 14, 2019·The Journal of Dermatology·Ao Wang, YanPing Bai
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Apr 25, 2019·International Journal of Molecular Sciences·Alan V Nguyen, Athena M Soulika
Apr 10, 2019·Clinical and Experimental Immunology·J WallisR C Carlisle
Jul 29, 2020·International Journal of Molecular Sciences·Elena GroppaSerena Zacchigna
May 28, 2020·International Journal of Molecular Sciences·Momoko NakaoShinichi Sato
Nov 3, 2020·Drug Discovery Today·Audrey BayletLaurent Delpy
Apr 8, 2019·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger

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Methods Mentioned

BETA
gene knockout
single cell sequencing
xenograft

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