The origin of spontaneous synchronized burst in cultured neuronal networks based on multi-electrode arrays

Bio Systems
Chuanping ChenQingming Luo

Abstract

Many neural networks in mammalian central nervous system (CNS) fire single spike and complex spike burst. In fact, the conditions for triggering burst are not well understood. In the paper multi-electrode arrays (MEA) are used to record the spontaneous electrophysiological activities of cultured rat hippocampal neuronal network for a long time. After about 3 weeks culture, a transition from single spike to burst is observed in several networks. All of these spikes fire quickly before burst begins. The firing rate during the burst is lower than that just before the burst, but differences of inter-spike intervals (ISIs) between two firing patterns are not clear. Moreover, the electrical activities on neighboring electrodes show strong synchrony during the burst activities. In a word, the generation of the burst requires that network should have a sufficient level of excitation as well as a balance of synaptic inhibition.

References

Nov 17, 1995·Science·M MeisterD A Baylor
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Mar 12, 2002·The European Journal of Neuroscience·Pascal DarbonJürg Streit
Mar 23, 2002·Physical Review Letters·Ronen SegevEshel Ben-Jacob
Dec 9, 2003·Nature Reviews. Neuroscience·Rüdiger Krahe, Fabrizio Gabbiani

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Citations

Jan 29, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Lin ChenShaoqun Zeng
Sep 1, 2015·Current Neurology and Neuroscience Reports·Ryan S Dhindsa, David B Goldstein
Jan 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuxin ZhouXuanmao Chen
Jul 24, 2021·Cerebral Cortex Communications·Ravi KumarChi-Keung Chan

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