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The origin of the alkaline inactivation of pepsinogen

Biochemistry

Dec 2, 1975

Peter McPhie

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Abstract

Above pH 8.5, pepsinogen is converted into a form which cannot be activated to pepsin on exposure to low pH. Intermediate exposure to neutral pH, however, returns the protein to a form which can be activated. Evidence is presented for a reversible, small conformational change in the mol...read more

Mentioned in this Paper

Neutralization - ActCode
Inactivation
PEPSINOGEN GENE
Pepsinogens
Protein Conformation
Pepsinogen A
Hydrogen-Ion Concentration
Pepsin A
Spectrophotometry, Ultraviolet
Titration Method
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  • The origin of the alkaline inactivation of pepsinogen

    Biochemistry

    Dec 2, 1975

    Peter McPhie

    PMID: 44

    DOI: 10.1021/bi00695a003

    Abstract

    Above pH 8.5, pepsinogen is converted into a form which cannot be activated to pepsin on exposure to low pH. Intermediate exposure to neutral pH, however, returns the protein to a form which can be activated. Evidence is presented for a reversible, small conformational change in the mol...read more

    Mentioned in this Paper

    Neutralization - ActCode
    Inactivation
    PEPSINOGEN GENE
    Pepsinogens
    Protein Conformation

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