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The origin of the alkaline inactivation of pepsinogen

Biochemistry

Dec 2, 1975

P McPhie

Abstract

Above pH 8.5, pepsinogen is converted into a form which cannot be activated to pepsin on exposure to low pH. Intermediate exposure to neutral pH, however, returns the protein to a form which can be activated. Evidence is presented for a reversible, small conformational change in the mol...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Neutralization - ActCode
PEPSINOGEN GENE
Pepsin A
Pepsin 1
Pepsinogens
Protein Conformation
Spectrophotometry, Ultraviolet
Pepsinogen Measurement
Pepsinogen B
49
1
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The origin of the alkaline inactivation of pepsinogen

Biochemistry

Dec 2, 1975

P McPhie

PMID: 44

DOI: 10.1021/bi00695a003

Abstract

Above pH 8.5, pepsinogen is converted into a form which cannot be activated to pepsin on exposure to low pH. Intermediate exposure to neutral pH, however, returns the protein to a form which can be activated. Evidence is presented for a reversible, small conformational change in the mol...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Neutralization - ActCode
PEPSINOGEN GENE
Pepsin A
Pepsin 1
Pepsinogens
Protein Conformation
Spectrophotometry, Ultraviolet
Pepsinogen Measurement
Pepsinogen B
49
1

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