The origin of the genetic code

Origins of Life
M Ishigami, K Nagano

Abstract

A new approach to the origin of the genetic code is proposed based on some regularities in the nucleotide distribution pattern of the code. The relative amounts of various amino acids in primitive proteins were possibly different from those in organisms living today. The primordial ratio was supposed to shift to the modern one guided by the action of primitive nucleotides. Each primitive tRNA had a discriminator site and, distinguished from it, an anticodon site. It also postulated that primordially each amino acid could correspond to a wide variety of codons. During the course of the evolutionary change, a selective mechanism worked among the protobionts so that less frequent nucleotides became associated with more abundant amino acids in the primordial conditions,thus finally leading to the present codon catalogue.

References

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Citations

Sep 1, 1981·Origins of Life·L B HendryM Petersheim
Jan 1, 1986·Journal of Molecular Evolution·M KinjoM Ishigami
Mar 1, 1982·Origins of Life·R R Kocherlakota, N D Acland
Jul 27, 2017·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Toratane Munegumi, Naoya Tanikawa
Dec 1, 1977·Bio Systems·M IshigamiN Tonotsuka
Apr 20, 1978·Journal of Theoretical Biology·D L Rohlfing, M A Saunders

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