Complete genomic sequences from diverse phylogenetic lineages reveal notable increases in genome complexity from prokaryotes to multicellular eukaryotes. The changes include gradual increases in gene number, resulting from the retention of duplicate genes, and more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements. We argue that many of these modifications emerged passively in response to the long-term population-size reductions that accompanied increases in organism size. According to this model, much of the restructuring of eukaryotic genomes was initiated by nonadaptive processes, and this in turn provided novel substrates for the secondary evolution of phenotypic complexity by natural selection. The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies.
Comparative genomics reveals long, evolutionarily conserved, low-complexity islands in yeast proteins
Evolutionary pathways of the tirant LTR retrotransposon in the Drosophila melanogaster subgroup of species
Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus
Genome desertification in eutherians: can gene deserts explain the uneven distribution of genes in placental mammalian genomes?
The conflict between horizontal gene transfer and the safeguard of identity: origin of meiotic sexuality
A model of genetic search for beneficial mutations: estimating the constructive capacities of mutagenesis
Evolution of an ancient microsatellite hotspot in the conifer mitochondrial genome and comparison with other plants
Vertical inheritance and bursts of transposition have shaped the evolution of the BS non-LTR retrotransposon in Drosophila
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Relaxed natural selection alone does not permit transposable element expansion within 4,000 generations in Escherichia coli
"Hypothesis for the modern RNA world": a pervasive non-coding RNA-based genetic regulation is a prerequisite for the emergence of multicellular complexity
Differential GC content between exons and introns establishes distinct strategies of splice-site recognition
Organisation of trypsin genes in the salmon louse (Lepeophtheirus salmonis, Crustacea, copepoda) genome
Nutrient requirements for growth of the extreme oligotroph 'Candidatus Pelagibacter ubique' HTCC1062 on a defined medium
Demography and weak selection drive patterns of transposable element diversity in natural populations of Arabidopsis lyrata
Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.