PMID: 8601819Apr 1, 1996Paper

The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
C J Wilson, Y Kawaguchi

Abstract

In vivo intracellular recordings of spontaneous activity of neostriatal spiny cells revealed two-state behavior, i.e., characteristic shifts of membrane potential between two preferred levels. The more polarized level, called the Down state, varied among neurons from -61 to -94 mV. The more depolarized level, called the Up state, varied among neurons form -71 to -40 mV. For any one neuron, the membrane potential in the Up and Down states was constant over the period of observation (from 15 min to 4 hr), and the cells spent little time in transition between states. The level of membrane potential noise was higher in the Up state than in the Down state. Spontaneous membrane potential fluctuations were not abolished by experimental alteration of the membrane potential, but the time spent in each state was altered when intracellular current was used to vary the baseline membrane potential. Neither the sodium nor the calcium action potential that could be evoked by depolarization of spiny neurons was required for the occurrence of spontaneous shifts of membrane potential. Blockade of these action potentials using intracellular injection of QX314 and D890, respectively, altered neither the incidence of the membrane potential shifts n...Continue Reading

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