PMID: 11335116May 4, 2001Paper

The orphan nuclear receptor BmHR3A of Bombyx mori: hormonal control, ovarian expression and functional properties

Mechanisms of Development
T EystathioyK Iatrou

Abstract

Ovarian development in the domesticated silkmoth, Bombyx mori, is induced by the molting hormone 20-hydroxy-ecdysone (20E) shortly after larval-pupal ecdysis. Studies of the ecdysone response in Drosophila and other insects have shown that 20E exerts its effects initially by the induction of a small number of early genes, including the orphan nuclear receptors HR3, that transduce and amplify the hormone signal. Here we show that the silkmoth orphan receptor BmHR3A acts in the 20E-induced regulatory cascade in the ovary during pupal and pharate adult development in a manner different than that observed in the classical ecdysone regulatory hierarchy in Drosophila salivary glands at the end of the third instar. While other isoforms of BmHR3 are induced as early gene products in the ecdysone response, BmHR3A is induced 2 days after 20E administration in the silkmoth ovary and, thus, behaves as late product. The period of accumulation of BmHR3A in ovarian follicular cells occurs during vitellogenesis and coincides with the period of transcriptional expression of the ESP (egg-specific protein) gene, whose product constitutes a major component of the egg yolk, while it is reciprocal to the period of expression of BmGATAbeta, a gene en...Continue Reading

References

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Citations

Mar 17, 2010·Functional & Integrative Genomics·Yimei CaiJun Yu
Nov 6, 2003·Insect Biochemistry and Molecular Biology·Luc Swevers, Kostas Iatrou
Apr 30, 2013·BMC Genomics·Jean-Michel CarterCasper J Breuker
Mar 30, 2010·General and Comparative Endocrinology·Bethany R HannasGerald A LeBlanc
Apr 15, 2008·Insect Biochemistry and Molecular Biology·David SiaussatStéphane Debernard
Sep 8, 2010·Journal of Insect Physiology·Hadi MosallanejadGuy Smagghe
Feb 12, 2019·Pest Management Science·Xiaoyu ChengBing Li
Aug 30, 2002·The Journal of Biological Chemistry·Luc SweversKostas Iatrou
Nov 25, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luc SweversKostas Iatrou
Apr 4, 2017·PloS One·Suphawan SuangPanuwan Chantawannakul
Aug 5, 2008·Insect Biochemistry and Molecular Biology·Luc SweversGuy Smagghe

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