The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction

Physiological Reviews
Marie-Charlotte MeinsohnBruce D Murphy

Abstract

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified signaling ligands are designated orphan nuclear receptors. Two of these, steroidogenic factor-1 (NR5A1, also known as SF-1) and liver receptor homolog-1 (NR5A2, also known as LRH-1), bind to the same DNA sequences, with different and nonoverlapping effects on targets. Endogenous regulation of both is achieved predominantly by cofactor interactions. SF-1 is expressed primarily in steroidogenic tissues, LRH-1 in tissues of endodermal origin and the gonads. Both receptors modulate cholesterol homeostasis, steroidogenesis, tissue-specific cell proliferation, and stem cell pluripotency. LRH-1 is essential for development beyond gastrulation and SF-1 for genesis of the adrenal, sexual differentiation, and Leydig cell function. Ovary-specific depletion of SF-1 disrupts follicle development, while LRH-1 depletion prevents ovulation, cumulus expansion, and luteinization. Uterine depletion of LRH-1 compromises decidualization and pregnancy. In humans, SF-1 is present in endometriotic tissue, where it regulates estrogen synthesis. SF-1 is underexpressed in ovarian cancer cells and overe...Continue Reading

References

Oct 1, 1991·Molecular Endocrinology·D A RiceK L Parker
Sep 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K ShinodaO Niwa
Feb 1, 1996·Biology of Reproduction·J F StraussM Kiriakidou
Jul 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·V PezziW E Rainey
Oct 1, 1996·Journal of Molecular Endocrinology·M WongK L Parker
Jun 1, 1997·Obstetrical & Gynecological Survey·I P Ryan, R N Taylor
Jun 1, 1997·Endocrine Reviews·K L Parker, B P Schimmer
Jul 1, 1997·Molecular and Cellular Biology·P A CrawfordJ Milbrandt
May 5, 1998·Molecular and Cellular Biology·P A CrawfordJ Milbrandt
Apr 30, 1999·Science·S A KliewerT M Willson
Jul 20, 1999·The Journal of Biological Chemistry·Y K LeeD D Moore
Nov 24, 1999·The Journal of Biological Chemistry·Y KabeH Handa
Jul 6, 2000·The Journal of Comparative Neurology·T L DellovadeS A Tobet
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H EscrivaV Laudet
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L BlandH A Ingraham

❮ Previous
Next ❯

Citations

Jun 20, 2019·Expert Review of Molecular Diagnostics·Alberto FerlinCarlo Foresta
May 7, 2020·Journal of Clinical Medicine·Anna ZubrzyckaMaria Zubrzycka
Sep 2, 2020·Cells·Prashanta SilwalEun-Kyeong Jo
Nov 25, 2020·Biology of Reproduction·Wei Yan
Mar 12, 2021·G3 : Genes - Genomes - Genetics·Allison N BeachumElizabeth T Ables
Dec 9, 2020·Molecular Aspects of Medicine·Camilla H K Hughes, Bruce D Murphy
Apr 24, 2021·Frontiers in Cell and Developmental Biology·Xiaohua HuangGanggang Shi
Apr 23, 2021·Endocrine Regulations·Alzbeta Bujnakova Mlynarcikova, Sona Scsukova
Aug 23, 2020·Molecular and Cellular Endocrinology·Hélène HolotaDavid H Volle
Sep 26, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dimitrios GkikasPanagiotis K Politis
Oct 14, 2021·Molecular Biology Reports·Nikita SandhuKiran Meena

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
acetylation
ubiquitination
immunoprecipitation
ChIP
transgenic

Software Mentioned

Molecular Evolutionary Genetics Analysis
BLAST

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
Kyren A LazarusColin D Clyne
Frontiers in Bioscience : a Journal and Virtual Library
Yoon-Kwang Lee, D D Moore
© 2022 Meta ULC. All rights reserved