The orphanin FQ/nociceptin (OFQ/N) system

Results and Problems in Cell Differentiation
O Civelli

Abstract

Orphanin FQ/nociceptin (OFQ/N) was the first novel neuropeptide discovered as the natural ligand of an orphan G protein-coupled receptor (GPCR). Orphan GPCRs are proteins classified as receptors on the basis of their sequence similarities to known GPCRs but that lack the ligands that activate them in vivo. One such orphan GPCR exhibited sequence similarities with the opioid receptors. OFQ/N was isolated as its natural ligand and shown to also share sequence similarities to the opioid peptides. This led to numerous studies attempting to find functional similarities and differences between the OFQ/N and opioid systems. This chapter will summarize our knowledge of the OFQ/N system and of its roles in the organism.

Citations

Feb 2, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Benito AntonToby K Eisenstein
Apr 16, 2009·International Review of Psychiatry·Sandra P Welch
Oct 14, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Agostini, C Petrella
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B A Gosnell, A S Levine
May 19, 2012·Nature Reviews. Drug Discovery·Guy Griebel, Florian Holsboer
Aug 31, 2013·Nature Reviews. Drug Discovery·Guy Griebel, Andrew Holmes
Feb 26, 2010·Expert Opinion on Therapeutic Patents·Tally M Largent-Milnes, Todd W Vanderah
Jul 21, 2012·Bulletin of Experimental Biology and Medicine·E A IvanovaA A Kamensky
May 17, 2011·Biochemistry. Biokhimii︠a︡·S V Gein, T A Baeva
Oct 2, 2012·Annual Review of Pharmacology and Toxicology·Olivier CivelliHelgi B Schiöth
May 7, 2010·The AAPS Journal·Akihiko OzawaWesley K Kroeze
May 10, 2020·Current Topics in Medicinal Chemistry·Norikazu KiguchiMei-Chuan Ko

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