The orphanin receptor agonist RO 64-6198 does not induce place conditioning in rats

Neuroreport
Gwenaëlle Le PenF Jenck

Abstract

The abuse liability of Ro 64-6198, an orphanin FQ (OFQ) receptor full agonist that exhibits anxiolytic properties, was evaluated using an unbiased conditioned place preference (CPP) paradigm in rats. As OFQ is structurally related to opioid peptides and also exhibits anxiolytic-like properties, the effect of Ro 64-6198 on CPP was compared with those of morphine and alprazolam. We show here that neither Ro 64-6198 nor alprazolam exhibited rewarding or aversive properties, whereas morphine induced a pronounced CPP. These results strengthen the previous finding that Ro 64-6198 lacked abuse liability in a self-stimulation paradigm, suggesting that this new class of anxiolytic drugs is devoid of the risk for potential non-medical use and dependence.

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Apr 23, 2003·Brain Research·Scott J RussoVanya Quinones-Jenab
May 17, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Jean-Claude Meunier
Sep 26, 2014·Expert Opinion on Drug Discovery·Chris P Bailey, Stephen M Husbands
Jan 22, 2005·European Journal of Pharmacology·Chinami OkabeNiall P Murphy
Oct 9, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fabian FernandezDarragh P Devine
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hanns Ulrich Zeilhofer, Girolamo Calò

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