The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration

Biomaterials Science
Zetao ChenYin Xiao

Abstract

A barrier membrane is a major component of guided bone regeneration (GBR), which is traditionally viewed as a physical barrier. Due to its "foreign body" nature, the implantation of a barrier membrane would inevitably modulate immune response and subsequently affect bone dynamics, which has long been neglected. To bridge this knowledge gap, we investigated the osteoimmunomodulatory effects of barrier collagen membranes. It is found that barrier collagen membranes elicit significant effects on modulating the osteoimmune response of macrophages, by upregulating the expression of pro-inflammatory cytokines (TNFα, IL-1β, IL-6, and IL-18) and osteogenic factors (BMP2/6, WNT10b, OSM). The modulated-osteoimmune environment was beneficial for the osteogenic differentiation of BMSCs, due to the activation of BMP, canonical WNT/β-catenin, and OSM signalling pathways. The membrane-mediated osteoimmunomodulation was further modulated to show whether osteogenesis could be enhanced via manipulating the membrane-mediated osteoimmunomodulation. The membrane-mediated osteoimmune response was successfully tuned through coating the collagen membranes with nanometer-sized bioactive glass Ca2ZnSi2O7 by pulsed laser deposition, which is indicated fr...Continue Reading

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Citations

Apr 29, 2018·Journal of Tissue Engineering and Regenerative Medicine·Chenyu ChuYili Qu
Feb 26, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bin GuoXiaohui Rausch-Fan
Sep 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Joanna M Sadowska, Maria-Pau Ginebra
May 4, 2021·Advanced Healthcare Materials·Yiting LouBinbin Ying
Jun 5, 2021·Acta Biomaterialia·Gemma MestresAnna Diez-Escudero
Jun 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min HeWeidong Tian
Aug 22, 2021·Acta Biomaterialia·Kai ZhengAldo R Boccaccini
Sep 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanlin LongLili Chen

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Methods Mentioned

BETA
density gradient centrifugation
ELISA

Software Mentioned

SPSS
BLAST
Image J

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