The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: A review of in vivo and in vitro studies

Environmental Toxicology and Pharmacology
Jian Zhang

Abstract

Osteoporosis is a progressive systemic disease characterized by low bone mineral density and deterioration of bone microarchitecture. The current therapies are effective to prevent further bone loss and fractures but they are accompanied by undesirable side effects and cost issues. The discovery of Chinese herbal medicines with osteoprotective effects provides alternative treatments to prevent bone loss without causing severe side effects. Artemisinin (ARS) and its related compounds have been clinically used as antimalarial agents. Interestingly, their bioactivity is not limited to antimalarial treatment. Experimental evidences indicate that ARS compounds are a potential type of therapeutic alternative medicine for bone loss induced by accelerated osteoclastic bone resorption. The present review intends to summarize the current understandings of ARS compounds and their molecular mechanisms of actions in preventing bone loss. ARS compounds selectively inhibit osteoclast differentiation by downregulation of pathways involved in receptor activator of nuclear factor kappa-B ligand (RANKL) -induced osteoclastogenesis, and have no effect on osteogenic differentiation of osteoblasts. The exact mechanism of activation and action of the...Continue Reading

References

Sep 1, 2004·Free Radical Biology & Medicine·Thomas EfferthManfred Marschall
Sep 28, 2005·Expert Opinion on Therapeutic Targets·Henry LaiNarendra P Singh
Oct 19, 2007·International Journal of Pharmaceutics·Ikuhiko NakaseTomikazu Sasaki
Aug 5, 2008·Bioorganic & Medicinal Chemistry·Shiming Zhang, Glenn S Gerhard
Sep 9, 2009·Toxicology Letters·Kanako Yamasaki, Hiromi Hagiwara
Feb 18, 2010·Critical Reviews in Toxicology·Thomas Efferth, Bernd Kaina
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul M O'NeillStephen A Ward
Oct 13, 2010·Annual Review of Pathology·Xu Feng, Jay M McDonald
Aug 28, 2012·Acta Pharmacologica Sinica·Ying Li
Mar 26, 2015·Journal of Bone and Mineral Metabolism·Danielle A Callaway, Jean X Jiang
Apr 11, 2015·Annals of Medical and Health Sciences Research·A K Das
Sep 27, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Edna OokoThomas Efferth
Sep 29, 2015·Oral and Maxillofacial Surgery Clinics of North America·Stuart Weinerman, Gianina L Usera
Dec 20, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lin ZhouJiake Xu
Jan 23, 2016·Redox Biology·Hiroyuki KanzakiYoshiki Nakamura
Mar 19, 2016·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Larissa K LaskowskiSilas W Smith
Jul 16, 2016·Pharmacology & Therapeutics·Lifei Hou, Haochu Huang
Nov 5, 2016·Annual Review of Medicine·Jie AnKeith B Elkon
May 30, 2017·Biochimica Et Biophysica Acta. General Subjects·Gladys O Latunde-Dada
Jul 12, 2017·The Lancet. Diabetes & Endocrinology·Sundeep Khosla, Lorenz C Hofbauer
Dec 25, 2017·Bone·Timothy R Arnett, Isabel R Orriss
Feb 17, 2018·Connective Tissue Research·Jian ZhangGuangming Zhou
Apr 11, 2018·Natural Products and Bioprospecting·Yunqin ZhangZhili Zuo
Apr 20, 2018·Cellular and Molecular Life Sciences : CMLS·Kyung-Hyun Park-Min
May 16, 2018·Experimental Biology and Medicine·Xingtao GeYu Yang
Sep 12, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Gwang Taek MaWon-Yoon Chung
Mar 31, 2019·Journal of Hematology & Oncology·Yanhua MouBin Li
Jun 13, 2019·Nature Reviews. Immunology·Masayuki Tsukasaki, Hiroshi Takayanagi

❮ Previous
Next ❯

Citations

Jul 11, 2020·International Journal of Molecular Sciences·Ioannis TsamesidisKarine Reybier
Mar 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kai ZhengZhendan He
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jia-Yue DuanLing-Qing Yuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Femke A MauritzDavid C van der Zee
Journal of the American College of Radiology : JACR
Jannette Collins
Danish Medical Bulletin
Jacob Vad JensenAnne-Kathrine Hove Faxholt
American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
Sunjay Suri
© 2021 Meta ULC. All rights reserved