The "other" mTOR complex: New insights into mTORC2 immunobiology and their implications

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Helong Dai, Angus W Thomson

Abstract

A central role of the mechanistic target of rapamycin (mTOR) in regulation of fundamental cell processes is well recognized. mTOR functions in two distinct complexes: rapamycin-sensitive mTOR complex (C) 1 and rapamycin-insensitive mTORC2. While the role of mTORC1 in shaping immune responses, including transplant rejection, and the influence of its antagonism in promoting allograft tolerance have been studied extensively using rapamycin, lack of selective small molecule inhibitors has limited understanding of mTORC2 biology. Within the past few years, however, intracellular localization of mTORC2, its contribution to mitochondrial fitness, cell metabolism, cytoskeletal modeling and cell migration, and its role in differentiation and function of immune cells have been described. Studies in mTORC2 knockdown/knockout mouse models and a new class of dual mTORC1/2 inhibitors, have shed light on the immune regulatory functions of mTORC2. These include regulation of antigen-presenting cell, NK cell, T cell subset, and B cell differentiation and function. mTORC2 has been implicated in regulation of ischemia/reperfusion injury and graft rejection. Potential therapeutic benefits of antagonizing mTORC2 to inhibit chronic rejection have al...Continue Reading

References

Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Apr 11, 2006·Molecular Cell·Dos D SarbassovDavid M Sabatini
Aug 22, 2006·Nature·Li-Fan LuRandolph J Noelle
Apr 11, 2007·Developmental Cell·Prashanth T Bhaskar, Nissim Hay
Apr 25, 2009·Nature Reviews. Immunology·Angus W ThomsonGiorgio Raimondi
Oct 9, 2009·Journal of Cell Science·Mathieu Laplante, David M Sabatini
Feb 12, 2011·The Journal of Biological Chemistry·Xiaoqing GanDianqing Wu
Mar 4, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y-P JinE F Reed
Aug 2, 2014·PloS One·Yingchi ZhangWeiping Yuan
Oct 14, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B R RosboroughA W Thomson
Nov 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas PrevotCheong-Hee Chang
Jan 7, 2015·Nature Immunology·Alexandria HuynhLaurence A Turka
Jan 7, 2015·Nature Immunology·Sharad ShresthaHongbo Chi
Apr 5, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dàlia Raïch-ReguéAngus W Thomson
Apr 22, 2015·The Journal of Clinical Investigation·Kristen N PollizziJonathan D Powell
Jan 20, 2016·Nature Immunology·Peter J Murray
Feb 26, 2016·British Journal of Haematology·Ma Carmen Herrero-SánchezBelén Blanco
May 11, 2016·Trends in Biochemical Sciences·Christl GaubitzRobbie Loewith
Nov 2, 2016·The Journal of Biological Chemistry·Lee-Ann Van de Velde, Peter J Murray
Jan 13, 2017·European Journal of Immunology·Tammarah SklarzMartha S Jordan
Feb 2, 2017·The Journal of Cell Biology·Michael EbnerIvan Yudushkin
Mar 12, 2017·Cell·Robert A Saxton, David M Sabatini
May 24, 2017·Current Opinion in Immunology·Hu Zeng, Hongbo Chi
Jun 11, 2017·FEBS Letters·Monika LinkeThomas Weichhart

❮ Previous
Next ❯

Citations

Nov 23, 2019·International Journal of Molecular Sciences·Petra Hillmann, Doriano Fabbro
Oct 6, 2020·Frontiers in Immunology·Tünde FeketeKitti Pázmándi
Jul 13, 2021·Aging Cell·Josué Ballesteros-Álvarez, Julie K Andersen
Jan 28, 2022·Molecular Biology Reports·Parvaneh MovahhedHossein Teimori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Transplant Immunology
Masanori Abe, Angus W Thomson
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Daniel Fantus, Angus W Thomson
Current Opinion in Investigational Drugs
Shripad V Bhagwat, Andrew P Crew
© 2022 Meta ULC. All rights reserved