The ototoxic potential of cobalt from metal-on-metal hip implants: a pilot study on the patient-reported auditory, vestibular, and general neurological outcome.

International Journal of Audiology
Laura LeyssensLeen Maes

Abstract

This study aimed to systematically investigate the ototoxic potential of cobalt in patients with a metal-on-metal (MoM) hip implant, using objective auditory and vestibular assessments and a questionnaire. The results of the objective evaluation were published previously, whereas the current study focused on the questionnaire outcome and its relationship to the blood cobalt level. Design and study sample: Twenty patients (33-65 years) with a primary MoM hip implant and 20 non-implanted control subjects, matched for age, gender, and noise exposure, received a questionnaire to evaluate the presence of several hearing and balance symptoms (part 1) and general neurological issues (part 2). Concerning part 1, the proportion of auditory-related symptoms in general (p = 0.022) and tinnitus (p = 0.047) was significantly higher in the MoM patient group, whereas no group difference was found for hyperacusis, increased listening effort, and decreased speech understanding. Concerning part 2, no significant group differences were detected. Within the MoM patient group, the questionnaire outcome was not significantly different between the low-exposure and high-exposure subgroups according to the blood Co level. In line with our previous stud...Continue Reading

References

Nov 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·J M MurphyS J Bishop
Apr 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·H M Meecham, P Humphrey
Aug 1, 1996·Clinical Orthopaedics and Related Research·B G Weber
Sep 20, 2002·The New England Journal of Medicine·Alan H LockwoodRobert F Burkard
Nov 8, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·J W G MeijerT P Links
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sophie D FossåUNKNOWN Medical Research Council Testicular Cancer Study Group TE20
Oct 11, 2005·Drug Discovery Today·Leonard P Rybak, Craig A Whitworth
Nov 23, 2006·Hearing Research·Leonard P RybakVickram Ramkumar
Sep 2, 2008·The Journal of Bone and Joint Surgery. British Volume·D J LangtonA V F Nargol
Oct 7, 2008·The Journal of Arthroplasty·Alan M Kop, Eric Swarts
Feb 10, 2009·The Journal of the American Academy of Orthopaedic Surgeons·Joshua J JacobsMarkus A Wimmer
Sep 15, 2009·Indian Journal of Cancer·R AroraR K Seam
Aug 13, 2010·Journal of the American Academy of Audiology·Marilyn F DilleStephen A Fausti
Jun 7, 2011·Hearing Research·Jing XieJochen Schacht
Jun 23, 2011·The Medical Journal of Australia·Xinzhan MaoRoss W Crawford
Jul 7, 2011·Human & Experimental Toxicology·S CatalaniP Apostoli
Dec 14, 2011·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Reecha SachdevaArun D Singh
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Penelope R BrockEdward A Neuwelt
May 23, 2012·The Journal of Arthroplasty·Young-Min KwonAdolph V Lombardi
Aug 30, 2012·Clinical Orthopaedics and Related Research·Catherine Van Der StraetenKoen A De Smet
Oct 6, 2012·Lancet·Alison J SmithUNKNOWN National Joint Registry for England and Wales
Oct 17, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Pietro ApostoliRaffaele De Caro
May 10, 2013·Critical Reviews in Toxicology·Dennis J PaustenbachBrent D Kerger
Aug 21, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Bryan K WardCharles C Della Santina
Nov 22, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Dennis J PaustenbachBrent L Finley
Aug 7, 2014·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Christiaan P van LingenCees C P M Verheyen
Aug 12, 2014·American Journal of Audiology·Richard S TylerBrian C J Moore
Aug 19, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·S M BradberryR E Ferner
Dec 6, 2014·American Journal of Audiology·Martin PienkowskiBrian C J Moore
Feb 25, 2015·International Orthopaedics·Gulraj S MatharuRonan B C Treacy
Jun 16, 2015·Journal of Patient Safety·Bradford D GessnerStephen S Tower
Jul 15, 2015·Neurotoxicity Research·Peng LiJerome A Roth
Sep 15, 2015·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Raymond van de BergHerman Kingma
Oct 10, 2015·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Catherine Van Der Straeten, Koen A De Smet
Mar 15, 2016·Frontiers in Neurology·F LucieerRaymond van de Berg
May 5, 2016·Neurotoxicity Research·Jerome A Roth, Richard Salvi
May 22, 2016·Human & Experimental Toxicology·F FacchinA Beraudi
Jun 18, 2016·Frontiers in Surgery·Floris L WuytsLeen K Maes
Jun 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert D FrisinaLois B Travis
Sep 13, 2016·PloS One·M Charles LibermanStéphane F Maison
Dec 22, 2016·Clinical Pharmacology and Therapeutics·C Lanvers-KaminskyG Ciarimboli
Jan 15, 2017·Hearing Research·M Charles Liberman, Sharon G Kujawa
Jun 27, 2017·Ear and Hearing·Ruth Van HeckeLeen Maes
Jul 25, 2017·International Journal of Audiology·Beth Brooks, Kristin Knight
Sep 14, 2017·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·James H HoJeffrey Brent

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