The outcome of cancer patients with acute respiratory distress syndrome

Journal of Critical Care
Ayman O SoubaniDaryn Smith

Abstract

The objective of the study is to determine the 28-day mortality of critically ill cancer patients with acute respiratory distress syndrome (ARDS). This is a retrospective cohort study of patients enrolled in the ARDS Network randomized controlled trials. A total of 2515 patients did not have cancer, and 116 patients had cancer. Patients with cancer were older (median, 61 vs 49 years; P < .0001), more critically ill (the median Acute Physiology and Chronic Health Evaluation III score without cancer comorbidity was 105 for the cancer group compared with 87 for those without cancer; P < 0.0001), and more likely to have pneumonia or sepsis as cause of acute lung injury (79.31% vs 62.70%; P = .0011). The overall mortality at day 28 was 25.7%. Patients with cancer had significantly higher mortality (55.2%) compared with those without cancer (24.3%) (P < .0001). The odds ratio for mortality from ARDS at 28 days for cancer patients was 2.54 (95% confidence interval [CI], 1.570-4.120). Acute Physiology and Chronic Health Evaluation III score and age were found to be significant predictors of outcome in cancer patients with odds ratio of 1.034 (95% CI, 1.007-1.062; P = .0135) and 1.075 (95% CI, 1.024-1.129, P = .0036), respectively. Canc...Continue Reading

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Citations

May 23, 2015·Blood Reviews·Elie AzoulayUNKNOWN Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique (Grrr-OH)
Jul 28, 2015·Heart & Lung : the Journal of Critical Care·Ayman O SoubaniHyejeong Jang
Jan 19, 2018·Journal of Intensive Care Medicine·Gil Myeong SeongJin Won Huh
Jul 18, 2017·Rehabilitation Oncology·Amanda WeeksLouis Voigt
Jun 6, 2014·Intensive Care Medicine·Elie AzoulayMichael Darmon
Feb 16, 2017·Internal and Emergency Medicine·Alberto FerrareseGiovannella Baggio
May 4, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elżbieta KalicińskaTomasz Wróbel
Mar 23, 2021·American Journal of Respiratory and Critical Care Medicine·Guillaume DumasMichael Darmon

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