The outcome of heart transplantation in hepatitis C-positive recipients

Transplantation Proceedings
M-H LinS-S Wang

Abstract

Clinical outcomes of heart transplantation (HTx) among recipients with chronic hepatitis C virus (HCV) infection are poorly understood especially in Asia. Therefore, this study evaluated these clinical outcomes. Using retrospective chart review we collected data on 385 patients including 20 HCV-positive recipients at the time of transplantation. We obtained information on demographics features, serial transaminases, graft function, patient survival as well as the incidences of acute hepatitis and transplant coronary artery disease. Between 1987 and 2010, the 20 HCV-positive patients had a median age at transplantation of 52 years (range, 30-63). Seventeen were men and three women. All the patients were classified as Child-Pugh class A; two had cirrhosis prior to HTx. Over a mean follow-up of 63 months (range, 2 days to 187 months), there were 11 deaths, including two hospital mortalities and nine subsequent deaths. Only one mortality (5%) was related to Child-Pugh class C cirrhosis, despite liver transplantation. Among the other 19 deceased or surviving recipients, there was no evidence of hepatic dysfunction or hepatocellular carcinoma. Transplant coronary artery disease was detected in six patients (30%). There was no signifi...Continue Reading

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Citations

Jun 14, 2014·Cardiology in Review·Vasiliki KatsiIoannis Kallikazaros
Jan 29, 2016·World Journal of Gastroenterology : WJG·Sara Belga, Karen Elizabeth Doucette
May 24, 2018·Current Infectious Disease Reports·Lucy Somerville, Karen Doucette
Nov 16, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Martina VitroneRosa Zampino

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