The outcome of idiopathic dilated cardiomyopathy and myocarditis in children from the west of Scotland

International Journal of Cardiology
P VenugopalanA K Agarwal

Abstract

We analysed retrospectively all infants and children with idiopathic dilated cardiomyopathy (IDC) and myocarditis at the Regional Cardiac Centre of the Royal Hospital for Sick Children, Glasgow, during 1980-1997. Among the 39 patients with IDC, 25 (64%) were infants aged < 1 year, eight (20.5%) had wheezing as the presenting symptom, and only six (15%) had a significant cardiac murmur. Thirty-eight of thirty-nine patients diagnosed in life were followed-up for 1 day to 15 years (median 3 years). Twelve of the thirty-nine (31%) died, six deaths were within a week of presentation and the rest within a year. The survival at 1 year and at 12 years was 0.69 (95% CI 0.54 to 0.84). Fourteen patients had histologically proven myocarditis, and all 9/14 (64%) detected at post-mortem and one of the five diagnosed in life died. Patients with myocarditis exhibited an actuarial survival of 0.29 (95% CI 0.04 to 0.53) at 1 year and at 9 years, significantly lower than IDC patients (log rank 9.8, P < 0.01). There was no difference in the outcome for patients with positive or negative Coxsackie titres or who presented in the 1980s and in the 1990s. No risk factor that independently influenced the outcome or survival could be identified in either...Continue Reading

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Citations

Apr 25, 2003·The New England Journal of Medicine·Alan W NugentUNKNOWN National Australian Childhood Cardiomyopathy Study
Apr 11, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hisashi SugiyamaKanji Sugita
Sep 1, 2007·Progress in Pediatric Cardiology·Jorge A AlvarezSteven E Lipshultz
Nov 23, 2006·Circulation·Piers E F DaubeneyUNKNOWN National Australian Childhood Cardiomyopathy Study
Mar 1, 2014·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Bradley M OkdieLauren Reichart Smith
Jun 13, 2019·European Journal of Pediatrics·Muhammad Bassem Jammal AddinLindsey Hunter

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