The outcome of intra-cytoplasmic sperm injection (ICSI): do the sperm concentration and motility matter?

Hormone Molecular Biology and Clinical Investigation
Ai Chen ChuaMohd Faizal Ahmad

Abstract

The male-factor subfertility was reported to be 30% globally; thus, the intracytoplasmic sperm injection (ICSI) procedure was implemented to improve the overall in vitro fertilization (IVF) rates. Nevertheless, at least 10% of fertilization failure still occurs. Concerning this issue, we explored the association of sperm concentration and motility with the quality of embryo development and pregnancy outcome in IVF-ICSI cycles. Retrospective analysis of 109 couples with male factor were done over 14 months in a tertiary university hospital in Malaysia. The data were divided into four groups; Group I: normal sperm parameters, Group II: normal sperm concentration but reduced total sperm motility, Group III: reduced sperm concentration and motility, Group IV: reduced sperm concentration but normal sperm motility. Only fresh semen samples and fresh embryo transfers were included. The fertilization, cleavage rate, embryo quality and pregnancy outcome were assessed. Overall, group I had the highest oocytes yield and ICSI attempted; (10.12 + 6.50), whereas the lowest was in group IV; (7.00 + 2.82). Group II revealed the highest fertilization and cleavage rates; (54.14 + 25.36), (55.16 + 26.06), thus not surprisingly resulting in the hi...Continue Reading

References

May 1, 1990·Human Reproduction·P BarlowF Leroy
Jul 15, 2003·Current Opinion in Obstetrics & Gynecology·Neal G Mahutte, Aydin Arici
Jul 8, 2008·Human Reproduction Update·Jason E Swain, Thomas B Pool
Jun 26, 2014·Journal of Assisted Reproduction and Genetics·Inci KahyaogluLeyla Mollamahmutoglu
May 1, 2015·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalMichelle Renee Chyatte

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