The outcome of pregnancy in women with cystic fibrosis: a UK population-based descriptive study.

BJOG : an International Journal of Obstetrics and Gynaecology
A AshcroftL Mackillop

Abstract

To estimate the incidence of cystic fibrosis in pregnancy and to explore obstetric and neonatal outcomes. A population-based descriptive study using the methodology of the UK Obstetric Surveillance System (UKOSS). All consultant-led maternity units in the UK. All pregnant women with a diagnosis of cystic fibrosis who booked for antenatal care in a UK obstetric unit between March 2015 and February 2017. Prospective case collection identified using UKOSS monthly notification. Incidence, maternal morbidity, maternal mortality, gestation at delivery, neonatal mortality, neonatal morbidity. We report 71 pregnancies over a 2-year period. There was one early miscarriage, four terminations and three sets of twins, resulting in the live birth of 69 infants. There were no maternal deaths. One infant died following spontaneous preterm birth at 29 weeks' gestation. The mean gestation at delivery was 36.2 completed weeks. The mean birthweight centile for gestational age was the 61st centile. We report a positive correlation between both maternal lung function (FEV1 ) and mean gestation at delivery, and between FEV1 and mean birthweight centile for gestational age. Pregnancy outcomes are generally good in women with cystic fibrosis. Successf...Continue Reading

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Citations

Nov 24, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Jamie DuckersSiobhan Carr
Dec 29, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Anna AshcroftLucy Mackillop
Mar 26, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jennifer L Taylor-Cousar, Raksha Jain
Jun 3, 2021·Journal of Personalized Medicine·Raksha Jain, Jennifer L Taylor-Cousar
Aug 19, 2021·Pediatric Pulmonology·Traci M KazmerskiJennifer L Taylor-Cousar
Jul 21, 2021·Chest·Michal ShteinbergMalena Cohen-Cymberknoh
Aug 31, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Raksha JainJennifer L Taylor-Cousar

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