The outcomes of Perthes' disease of the hip: a study protocol for the development of a core outcome set.

Trials
Donato Giuseppe LeoDaniel Christopher Perry

Abstract

Perthes' disease is an idiopathic osteonecrosis of a developmental hip that is most frequent in Northern Europe. Currently, the absence of a common set of standardised outcomes makes comparisons between studies of different interventions challenging. This study aims to summarise the outcomes used in clinical research of interventions for Perthes' disease and define a set of core outcomes (COS) to ensure that the variables of primary importance are measured and reported in future research studies investigating Perthes' disease. A systematic review of the current literature will be used to identify a list of outcomes reported in previous studies. Additional important outcomes will be sought by interviewing a group of children with Perthes' disease, adults who were treated with the disease in infancy and parents of children with the disease. This list will then be evaluated by experts in Perthes' disease using a Delphi survey divided into two rounds to ascertain the importance of each outcome. The final outcomes list obtained from the Delphi survey will be then discussed during a consensus meeting of representative key stakeholders in order to define the COS to be reported in future clinical trials related to Perthes' disease. The...Continue Reading

References

Oct 1, 1988·British Journal of Urology·R I Hallan, A R May
Feb 1, 1996·Journal of Evaluation in Clinical Practice·A F Long, P Dixon
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Feb 16, 2011·Nurse Researcher·Joanna Smith, Jill Firth
Jul 12, 2011·The Orthopedic Clinics of North America·Daniel C Perry, Andrew J Hall
Nov 29, 2012·The Journal of Bone and Joint Surgery. British Volume·D C PerryA J Hall
Mar 4, 2014·Journal of Clinical Epidemiology·Maarten BoersPeter Tugwell
Aug 3, 2014·The Bone & Joint Journal·K L HaywoodM L Costa

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Citations

May 1, 2020·The Bone & Joint Journal·Donato G LeoDaniel C Perry
Nov 21, 2020·Bone & Joint Open·Yael GelferDeborah M Eastwood
Aug 21, 2021·The Bone & Joint Journal·Ben A MarsonUNKNOWN CORE-Kids collaborative group

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Software Mentioned

COS Delphi
OMERACT
Delphi
COMET
PRISMA
Rayyan

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