The outer membrane proteins UspA1 and UspA2 of Moraxella catarrhalis are highly conserved in nasopharyngeal isolates from young children

Vaccine
Patricia Stutzmann MeierChristoph Aebi

Abstract

UspA1 and UspA2 of Moraxella catarrhalis are vaccine candidates. The aims of this study were to determine: (1) the frequencies of occurrence and (2) the degrees of conservation of two surface-exposed epitopes of the uspA1 and uspA2 genes and their respective gene products in 108 nasopharyngeal isolates from young children. The uspA1 and uspA2 genes were detected in 107 (99%) and 108 (100%) isolates, respectively. Twenty-three of 108 uspA2 genes (21%) were identified as the variant gene uspA2H. One-hundred and five isolates (97%) expressed the mAb17C7-reactive epitope shared by UspA1 and UspA2, and 103 isolates (95%) reacted with the UspA1-specific mAb24B5. The only isolate which lacked a uspA1 gene demonstrated reduced adherence to HEp-2 cells and complement sensitivity. The data indicate that both uspA genes and the expression of at least two surface-exposed epitopes are virtually ubiquitous in isolates from a population at risk for otitis media. A vaccine capable of inducing a bactericidal immune response against the mAb17C7- and/or mAb24B5-reactive epitopes appears promising.

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Citations

Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George A SyrogiannopoulosNicholas G Beratis
Mar 14, 2003·The Pediatric Infectious Disease Journal·Patricia Stutzmann MeierChristoph Aebi
Jun 15, 2007·Infection and Immunity·Melanie M Pearson, Eric J Hansen
Nov 26, 2003·Infection and Immunity·Patricia Stutzmann MeierChristoph Aebi
May 23, 2003·Infection and Immunity·Arne ForsgrenKristian Riesbeck
Mar 25, 2004·Infection and Immunity·Melissa M HolmEric R Lafontaine
Nov 22, 2005·Infection and Immunity·Nadja HeinigerChristoph Aebi
Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Stefan P W de VriesPeter W M Hermans
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Dec 21, 2004·FEMS Immunology and Medical Microbiology·Pablo Yagupsky, Ariela Slonim
May 29, 2009·Clinical and Vaccine Immunology : CVI·Linda E Winter, Stephen J Barenkamp
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