PMID: 2111700May 15, 1990Paper

The oxidation of leucine in tumour-bearing rats

The Biochemical Journal
J M Argilés, F J López-Soriano

Abstract

Rats bearing the Walker-256 carcinosarcoma showed significant changes in leucine metabolism compared with their non-tumour-bearing controls. After a single intravenous tracer dose of L-[1-14C]leucine in vivo, 14CO2 release by tumour-bearing rats was significantly elevated throughout the time course of administration. In addition, both the clearance and turnover rates of the tracer were significantly enhanced in these animals. Incubation of soleus muscles from control and tumour-bearing rats in the presence of L-[1-14C]leucine revealed an enhanced oxidation of the amino acid in the tumour-bearing group. Tumour tissue slices were also able to oxidize the tracer at a similar rate to that found in soleus muscles from control animals.

Citations

Mar 23, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G VentrucciM C Gomes-Marcondes
Jul 5, 1995·Molecular and Cellular Biochemistry·C García-MartínezJ M Argilés
May 8, 1999·Medicinal Research Reviews·J M Argilés, F J López-Soriano
Apr 17, 2002·BMC Cancer·Gislaine VentrucciMaria Cristina Cintra Gomes-Marcondes
Jul 27, 2000·Journal of Cellular Physiology·S BusquetsJ M Argilés
Oct 25, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C C Gomes-MarcondesJ C Cooper
Apr 5, 2013·Biology of Reproduction·Laís Rosa Viana, Maria Cristina C Gomes-Marcondes
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C Gomes-MarcondesL Cury
Dec 21, 2005·The Journal of Nutrition·Vickie E Baracos, Michelle L Mackenzie
May 16, 2002·Journal of Cellular Physiology·Sílvia BusquetsJosep M Argilés
Sep 1, 1997·Medicinal Research Reviews·J M ArgilésF J López-Soriano
Nov 1, 1992·Medicinal Research Reviews·J M ArgilésF J López-Soriano
Nov 28, 2013·Cancer & Metabolism·Jason A ZastreStar Ye
Dec 21, 2005·The Journal of Nutrition·Haroon A ChoudryWiley W Souba
Dec 20, 2003·Biochemical and Biophysical Research Communications·Robert A HarrisNam Ho Jeoung
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Jan 31, 1992·Cancer Letters·J M Argilés, F J López-Soriano
Oct 4, 2011·Journal of Proteome Research·Bagganahalli S SomashekarAyyalusamy Ramamoorthy

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