PMID: 15402707Jan 20, 1950Paper

The oxidation of thiols by ionizing radiations

The Journal of General Physiology
E S G BARRON, V FLOOD

Abstract

Thiol compounds, such as glutathione, 2,3-dimercaptopropanol (BAL), propane-1,3-dithiol, and N-phenylaminopropanedithiol, were readily oxidized by x-rays, beta rays, and gamma rays. The ionic yield for this oxidation was about the same, 3 at pH 7, on irradiation with x-rays and with beta rays; it was 23 per cent less on irradiation with gamma rays. The ionic yield varied with the hydrogen ion concentration, increasing as the pH value increased. There was no reduction of oxidized glutathione on irradiation with dosages of x-rays and gamma rays which produced oxidation of the reduced compound. In the absence of oxygen, the oxidation of thiols by ionizing radiations was only 33 per cent of that obtained in the presence of dissolved oxygen. When the thiol solutions were irradiated in the presence of dissolved oxygen, catalase protected them from oxidation by 17 to 27 per cent.

References

Mar 20, 1949·The Journal of General Physiology·E S G BARRON, S DICKMAN

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Citations

Jan 1, 1952·A.M.A. Archives of Ophthalmology·L VON SALLMANN
May 1, 1952·Journal of Cellular Physiology. Supplement·D NACHMANSOHN
Jun 26, 1965·Nature·D L Dewey, J Beecher
Mar 1, 1954·Proceedings of the National Academy of Sciences of the United States of America·K Mikaelsen
Apr 1, 1960·Experimental Parasitology·C R SCHNEIDER
Jan 1, 1955·Archives of Biochemistry and Biophysics·S M SIEGEL, A W GALSTON
Feb 3, 1955·Annals of the New York Academy of Sciences·E S G BARRON
Jun 1, 1968·Kisaengch'unghak chapchi. The Korean journal of parasitology·Yong Hie Roh
Jul 1, 1960·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M K NERURKAR, M B SAHASRABUDHE
Jan 1, 1966·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J F Read, A Charlesby
Jan 1, 1958·Acta Pathologica Et Microbiologica Scandinavica·G F BAHR, G MOBERGER
Jul 1, 1960·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R LANGE, A PIHL
Jun 1, 1952·Bacteriological Reviews·O B WILLIAMSC R PHILLIPS
Oct 1, 1986·International Journal of Radiation Oncology, Biology, Physics·K OnoD C Shrieve

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