The oxidation states and chemical environments of iron and zinc as potential indicators of brain tumour malignancy grade - preliminary results

Metallomics : Integrated Biometal Science
Aleksandra WandzilakMarek Lankosz

Abstract

Despite the enormous advances in medicine, brain tumours are still among the lesser-known types of tumours and carry the worst prognoses. Transition metals are believed to play an essential role in carcinogenesis. The aim of this study was to determine differences in the average oxidation state and trends in the changes in the chemical environment of iron and zinc contained in healthy and neoplastic tissues of the human brain. For this purpose, X-ray Absorption Spectroscopy was used, which enables the study of disordered matter. The samples were taken intraoperatively and then immediately frozen to slow down chemical processes. Sixteen tumour samples with various malignancy grades were studied as well as one control sample. For each sample four to eight spectra were recorded, with a shift between them not greater than 0.2 eV. In all of the samples, iron occurred in compounds with both Fe(2+) and Fe(3+). However, the ratio of Fe(ii) to Fe(iii) content in the tissue visibly increased with the tumour malignancy grade. The change in the oxidation state of iron did not correlate with the hypoxia level of the tissues. Analysis of EXAFS spectra of zinc atoms showed that the chemical environment of zinc atoms differed with the tumour m...Continue Reading

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Citations

Sep 24, 2014·Redox Report : Communications in Free Radical Research·Vojislav BogosavljevićIvan Spasojević
May 6, 2015·Trends in Endocrinology and Metabolism : TEM·Claire Legendre, Emmanuel Garcion
Oct 21, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jan HrabetaVojtech Adam
Oct 1, 2016·Cancer Informatics·Zena M Hira, Duncan F Gillies
Dec 11, 2020·Metallomics : Integrated Biometal Science·Ashley L HollingsMark J Hackett

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