The oxidative response in the chronic constriction injury model of neuropathic pain

The Journal of Surgical Research
Edward C T H TanR Jan A Goris

Abstract

In the chronic constriction injury model of rat neuropathic pain, oxidative stress as well as antioxidants superoxide dismutase and reduced glutathione (GSH) are important determinants of neuropathological and behavioral consequences. Studies of the chronic constriction injury model observed (indirect) signs of inflammation. We, therefore, investigated the level of oxidative stress and antioxidant enzymes in skeletal muscle tissue of the rat hind paw and (jugular vein) plasma at d 7 after nerve injury. The level of reactive oxygen and nitrogen species (RONS) was determined as a measure of oxidative stress. Reduced GSH levels and the ceruloplasmin/transferrin ratio were determined as measures of overall antioxidant activity. RONS and overall antioxidant activity were measured in skeletal muscle tissue of the hind paw and jugular vein plasma. The level of RONS in muscle was determined using spin trapping combined with electron paramagnetic resonance spectroscopy. Using electron paramagnetic resonance spectroscopy, we also determined plasma levels of transferrin and ceruloplasmin. GSH levels were determined using high-performance liquid chromatography. In skeletal muscle tissue, the level of RONS was lower in nerve-injured hind pa...Continue Reading

References

Feb 1, 1985·Journal of the Neurological Sciences·M SadehL Z Stern
Apr 1, 1997·Free Radical Research·L van der LaanR J Goris

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Citations

Oct 18, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Benedetta IsacchiAnna Rita Bilia
May 11, 2016·BMC Musculoskeletal Disorders·Bijar GhafouriChrister Tagesson
Jun 14, 2016·Expert Opinion on Drug Delivery·Giovanni MonastraVittorio Unfer
Feb 13, 2015·Anais Da Academia Brasileira De Ciências·Gurpreet KaurAmteshwar S Jaggi
Jun 30, 2017·Forensic Sciences Research·Henry J Carson
Aug 31, 2011·Critical Reviews in Clinical Laboratory Sciences·Ivan Spasojević
Oct 21, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Muhammad ShahidZia Ud Din

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