PMID: 9679Jul 1, 1976

The oxygen affinity of chicken haemoglobin in whole blood and erythrocyte suspensions

Respiration Physiology
R M Wells

Abstract

The oxygen equilibrium of whole chicken blood has a P50 of 52.3 mm Hg and a Hill coefficient of 2.6 at pH 7.4 and 37 degrees C when determined with new microtechniques which are not vitiated by cellular respiration. The apparent failure of the haemoglobin to reach full saturation at arterial PO2 IS DISCUSSED IN RELATION TO THE HAEMoglobin-oxygen equilibrium concept. The low affinity observed is due to intraerythrocytic inositol pentaphosphate (IPP), and the affinity of a haemolysate "stripped" of IPP is greatly increased (deltalog P50 =1.25). Unlike the mamalian analogue 2, 3-diphosphoglycerate, IPP concentration of whole blood does not decrease after incubation for 10 hr at 37 degreesC.

References

Apr 1, 1975·Respiration Physiology·T Kawashiro, P Scheid
Mar 27, 1975·Nature·E R Huehns, A M Faroqui
Aug 1, 1975·Science·R E Isaacks, D R Harkness
Apr 1, 1971·The Journal of Cell Biology·C M Redman
Apr 1, 1973·Respiration Physiology·P L LutzK Schmidt-Nielsen
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Jun 1, 1974·Respiration Physiology·P L LutzK Schmidt-Nielsen
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Jul 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N JacksonJ Pearce
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Citations

May 1, 1977·Respiration Physiology·J P HolleP Scheid
Apr 1, 1983·Respiration Physiology·G N Lapennas, R B Reeves
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·M RieraJ Planas
Apr 1, 1988·Biological Chemistry Hoppe-Seyler·R E WeberG Braunitzer
Apr 1, 1983·Scandinavian Journal of Haematology·G P SummerfieldA J Bellingham

Related Concepts

Erythrocytes
Eryhem
Hydrogen-Ion Concentration
Inositol
Dioxygen
Oxygen Consumption
Oxyhemoglobin

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