PMID: 1319Aug 1, 1975

The oxygen transport system of red blood cells during diabetic ketoacidosis and recovery

J Ditzel, E Standl


Daily evaluations of 8 newly detected ketoacidotic diabetics showed the Bohr-effect of haemoglobin to be decreased by 50% while erythrocyte 2,3-DPG was decreased below 10 mumoles/g Hb. 2,3-DPG correlated strongly with pH during acidosis and with plasma inorganic phosphate (Pi) subsequently to the first insulin administration. Oxygen affinity of haemoglobin, measured as P50 act pH, was unchanged in ketoacidosis compared to the time, however, P50 act pH fell striking (p less than 0.001) and remained decreased up to 7 days depending upon the resynthesis of 2,3-DPG in relation to Pi. The Hill-coefeficient in reflecting the slope of the oxygen dissociation curve was diminished in ketoacidosis (p less than 0.005), and decreased further after pH-normalization (p less than 0.005). There was a close association of n with 2,3-DPG (p less than 0.001) and additionally with Pi at 2,3-DPG-levels below 10 mumoles/g Hb. Based on these findings a decreased erythrocyte oxygen release of one fifth during acidosis and more than one third after pH-correction can be hypothesised. In view of the intimate relation of Pi to the oxygen transport system it is suggesed that treatment of ketoacidosis should include Pi-sugstitution.


Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Ditzel
Nov 1, 1972·Clinics in Endocrinology and Metabolism·T D Hockaday, K G Alberti
Jan 1, 1973·Advances in Experimental Medicine and Biology·J Ditzel
Sep 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·G ArtursonB Zaar
Jun 3, 1972·British Medical Journal·K G Alberti, T D Hockaday
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·A Ericson, C H de Verdier
Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R E BeneschC I Yu
Feb 1, 1970·Journal of Applied Physiology·M A DuvelleroyM B Laver
Mar 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·A C Parekh, D H Jung
Mar 1, 1971·The Journal of Clinical Investigation·A J BellinghamC Lenfant
Jun 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·O Siggaard-Andersen, N Salling
Jun 1, 1971·Journal of Applied Physiology·A J Bellingham, C Lenfant
Jan 23, 1967·Biochemical and Biophysical Research Communications·R Benesch, R E Benesch
Jul 1, 1967·Archives of Biochemistry and Biophysics·A Chanutin, R R Curnish
Jan 1, 1948·Archives of Internal Medicine·M FRANKS, R F BERRIS


Apr 1, 1986·Diabetologia·J Møller-PetersenJ Ditzel
Jul 18, 1978·Pflügers Archiv : European journal of physiology·W Jelkmann, C Bauer
May 6, 1976·Pflügers Archiv : European journal of physiology·J Duhm
Dec 27, 1995·European Journal of Pharmacology·J NakamuraN Hotta
Feb 1, 1991·Journal of the Neurological Sciences·S D FarberR G Peterson
Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N Hotta
Dec 3, 1977·Lancet·S B Rosalki, J F Zilva
Mar 31, 1976·European Journal of Clinical Investigation·E Standl, H J Kolb
Jun 1, 1977·The Australian and New Zealand Journal of Surgery·J McCaffrey
Jun 1, 1978·The Australian and New Zealand Journal of Surgery·R G Larkins
Mar 25, 1978·British Medical Journal·J Ditzel, J J Kjaergaard
Oct 20, 1984·British Medical Journal·P J HaleM Nattrass
Sep 5, 2003·Postgraduate Medical Journal·D KamalakannanT A M Abdu
Oct 1, 1976·The Journal of Clinical Investigation·J F FitzgibbonsR T Jones
Aug 7, 2013·Seminars in Perinatology·Margarita de Veciana
May 15, 2012·Neurochemistry International·María M AdevaDavid Lamas
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Kari A Teramo
Jan 28, 2014·Obstetrics and Gynecology·Baha M Sibai, Oscar A Viteri
Oct 9, 2007·Obstetrics and Gynecology Clinics of North America·Jason A Parker, Deborah L Conway
Jun 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·L Landow, M S Visner
Feb 1, 1977·Metabolism: Clinical and Experimental·J Ditzel, J Dyerberg
Mar 1, 1996·Obstetrics and Gynecology Clinics of North America·V E WhitemanE A Reece
Mar 1, 1997·Renal Failure·E M HigaE Homsi
Mar 11, 2018·BMJ Case Reports·Yang Huang Grace NgHak Koon Tan
Nov 7, 2019·American Journal of Therapeutics·Angela Napoli
Jan 1, 1975·Acta Medica Scandinavica. Supplementum·J Ditzel, E Standl
Jan 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·R Juel

Related Concepts

Diphosphoglyceric Acids
Hydrogen-Ion Concentration
Diabetic Ketoacidosis

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.