The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid

Steroids
Peter J CrickWilliam J Griffiths

Abstract

Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification and quantification of a panel of twelve sterols in mouse cerebrospinal fluid (CSF) using liquid chromatography-mass spectrometry exploiting enzyme assisted derivatisation for sterol analysis technology. We found low levels of oxysterols and cholestenoic acids in CSF in the range of 5pg/mL-2.6ng/mL. As found in man, these concentrations are one to two orders of magnitude lower than in plasma.

References

Jan 1, 1993·Journal of Inherited Metabolic Disease·H J ten BrinkC Jakobs
Feb 7, 1997·The Journal of Biological Chemistry·J M LehmannT M Willson
Jan 25, 2003·Annual Review of Biochemistry·David W Russell
Feb 22, 2005·Journal of Lipid Research·Eoin FahyEdward A Dennis
Dec 11, 2008·Journal of Visualized Experiments : JoVE·Li Liu, Karen Duff
Mar 3, 2009·Molecular Aspects of Medicine·Ingemar BjörkhemSteve Meaney
Dec 10, 2009·The Journal of Biological Chemistry·Michael OgundareWilliam J Griffiths
Aug 1, 2012·Free Radical Biology & Medicine·William J GriffithsYuqin Wang
Aug 15, 2012·Journal of Lipid Research·Anna MeljonWilliam J Griffiths
Oct 2, 2014·The Journal of Clinical Investigation·Spyridon TheofilopoulosYuqin Wang
Feb 11, 2015·Steroids·Luigi IulianoWilliam J Griffiths

❮ Previous
Next ❯

Citations

Dec 8, 2015·The Journal of Steroid Biochemistry and Molecular Biology·William J GriffithsYuqin Wang
Nov 5, 2016·Progress in Lipid Research·Valentin MutembereziGiulio G Muccioli
Apr 14, 2016·Biochemical Society Transactions·William J GriffithsYuqin Wang
Mar 25, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Julia JunkerChristoph Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2022 Meta ULC. All rights reserved