The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival

Biochimie
Raju V S RajalaRobert E Anderson

Abstract

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylates the 3'OH of the inositol ring of phosphoinositides (PIs). They are responsible for coordinating a diverse range of cellular functions. Class IA PI3K is a heterodimeric protein composed of a regulatory p85 and a catalytic p110 subunit. In this study, we conditionally deleted the p110α-subunit of PI3K in cone photoreceptor cells using the Cre-loxP system. Cone photoreceptors allow for color vision in bright light (daylight vision). Cone-specific deletion of p110α resulted in cone degeneration. Our studies suggest that PI3K signaling is essential for cone photoreceptor functions.

Citations

Nov 25, 2016·Scientific Reports·Raju V S RajalaRobert E Anderson
Jul 28, 2020·Clinical & Experimental Ophthalmology·Cameron D HaydingerDaniel J Peet
Apr 8, 2020·Cells·Theodore G Wensel
Jun 11, 2020·Cells·Stella FinkelsteinEkaterina S Lobanova
Jun 17, 2020·Journal of Lipid Research·Raju V S Rajala
Feb 9, 2021·Journal of Lipid Research·Raju V S Rajala

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