The p53-mediated cytotoxicity of photodynamic therapy of cancer: recent advances

Toxicology and Applied Pharmacology
Joanna Zawacka-PankauGalina Selivanova

Abstract

Photodynamic therapy (PDT) is a promising modality for the treatment of both pre-malignant and malignant lesions. The mechanism of action converges mainly on the generation of reactive oxygen species which damage cancer cells directly as well as indirectly acting on tumor vasculature. The exact mechanism of PDT action is not fully understood, which is a formidable barrier to its successful clinical application. Elucidation of the mechanisms of cancer cell elimination by PDT might help in establishing highly specific, non-genotoxic anti-cancer treatment of tomorrow. One of the candidate PDT targets is the well-known tumor suppressor p53 protein recognized as the guardian of the genome. Together with its family members, p73 and p63 proteins, p53 is involved in apoptosis induction upon stress stimuli. The wild-type and mutant p53-targeting chemotherapeutics are currently extensively investigated as a promising strategy for highly specific anti-cancer therapy. In photodynamic therapy porphyrinogenic sensitizers are the most widely used compounds due to their potent biophysical and biochemical properties. Recent data suggest that the p53 tumor suppressor protein might play a significant role in porphyrin-PDT-mediated cell death by d...Continue Reading

Citations

Jul 6, 2012·Journal of Fluorescence·Magdalena Makarska-Bialokoz
Dec 15, 2010·FEBS Letters·Alicja SznarkowskaJoanna Zawacka-Pankau
Jul 9, 2013·Ultrasound in Medicine & Biology·Haiping WangQuanhong Liu
Jul 24, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Pilar Acedo, Joanna Zawacka-Pankau
Mar 6, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alicia ZamarrónÁngeles Juarranz
Dec 6, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Semra TasanEwen Bodio
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