The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter.

The Journal of Biological Chemistry
R V GopalkrishnanC Kedinger

Abstract

Cell cycle progression is subject to several regulatory controls, of which the p53 protein plays a major role in growth arrest, subsequent to the detection of cellular aberrations. It is well documented that p53 has the ability to inhibit transcription driven by several promoters, possibly via distinct mechanisms. In this report, we show that expression of the cell cycle regulatory transcription factor DP1 is strongly inhibited by p53, at the level of transcription and probably through the basal TATA-less promoter. This inhibitory activity has a relative specificity for the DP1 promoter compared with the functionally related E2F1 promoter or unrelated promoters such as those of the transcription factor ATFa or the thymidine kinase gene. Inhibition of DP1 transcription has implications in one of the several possible mechanisms through which p53 induces cell cycle arrest.

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Citations

Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bei WangEe Chee Ren
Sep 26, 2000·Molecular and Cellular Biology·P AriztiS W Lee
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A InnocenteJ M Lee
Jun 29, 2002·Molecular Endocrinology·Salvatore SciacchitanoMario Andreoli
Aug 26, 2006·The Journal of Biological Chemistry·Diederik Van BodegomSamir S El-Dahr
Jun 7, 2003·The Journal of Biological Chemistry·Jessica MarksSamir S El-Dahr
Oct 18, 2000·The Journal of Biological Chemistry·W R TaylorG R Stark
Apr 29, 2000·The Journal of Biological Chemistry·V JanssensJ Goris
Sep 26, 2001·The Journal of Biological Chemistry·L WangS Liu

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