The p53/Adipose-Tissue/Cancer Nexus

Frontiers in Endocrinology
Kevin ZwezdarykZubaida Saifudeen

Abstract

Obesity and the resultant metabolic complications have been associated with an increased risk of cancer. In addition to the systemic metabolic disturbances in obesity that are associated with cancer initiation and progression, the presence of adipose tissue in the tumor microenvironment (TME) contributes significantly to malignancy through direct cell-cell interaction or paracrine signaling. This chronic inflammatory state can be maintained by p53-associated mechanisms. Increased p53 levels that are observed in obesity exacerbate the release of inflammatory cytokines that fuel cancer initiation and progression. Dysregulated adipose tissue signaling from the TME can reprogram tumor cell metabolism. The links between p53, cellular metabolism and adipose tissue dysfunction and how they relate to cancer, will be presented in this review.

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Citations

Jun 7, 2019·Molecular Carcinogenesis·Pallavi Kompella, Karen M Vasquez
Dec 11, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ting ChenLinqi Chen

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Methods Mentioned

BETA
acetylation
neddylation

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