The p75 neurotrophin receptor is widely expressed in conventional papillary thyroid carcinoma

Human Pathology
Ana Sofia RochaManuel Sobrinho-Simões

Abstract

Papillary thyroid carcinomas (PTCs) are associated with alterations in several proto-oncogenes related with nervous system development and function, such as TrkA and RET, which are commonly rearranged in these carcinomas. The other oncogenic event recently identified in PTC is the BRAF V600E mutation. Because the role of TrkA was not completely elucidated in thyroid cancer ethiopathogenesis, we decided to study the expression of active, phosphorylated TrkA and of its coreceptor p75 neurotrophin receptor (p75 NTR) in a series of 92 PTC (37 lesions of conventional PTC, 28 of follicular variant of PTC [FVPTC], and 27 of other variants of PTC) as well as in 21 samples of normal thyroid and nonneoplastic thyroid lesions used as a controls. We observed neoexpression of p75 NTR in PTC, particularly in conventional PTC and in other variants of PTC displaying a papillary growth pattern, rather than in FVPTC. No immunoexpression of p75 NTR was observed in normal thyroid nor in nonneoplastic thyroid lesions. The cellular localization of p75 NTR immunoexpression was also significantly associated with the growth pattern of PTC, being much more frequently detected in an apical localization in PTC with papillary architecture than in PTC with ...Continue Reading

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Citations

Jul 3, 2007·Neoplasia : an International Journal for Oncology Research·Haifeng JinDaiming Fan
Jan 15, 2009·International Journal of Cancer. Journal International Du Cancer·Johannes H SchulteAngelika Eggert
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Vítor TroviscoManuel Sobrinho-Simões
Apr 14, 2016·Oncotarget·Sam FaulknerHubert Hondermarck
Feb 24, 2017·Journal of Biosciences·Fahimeh Hosseini AghdaeiMasoud Soleimani
Nov 21, 2018·International Journal of Molecular Sciences·Rui WangChangdong Wang
Sep 24, 2014·Molecular Cancer Research : MCR·Zuli YangJianping Wang
May 19, 2007·Molecular Cancer Research : MCR·Haifeng JinDaiming Fan

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