The p75 receptor is associated with inflammatory thermal hypersensitivity

Journal of Neuroscience Research
Tomoko WatanabeToshihide Yamashita

Abstract

Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through the actions of inflammatory mediators, and one of the key molecules is nerve growth factor (NGF). Here we report that the administration of neutralizing antibody to the neurotrophin receptor p75 (p75(NTR)) blocks hyperalgesia, which develops with complete Freund's adjuvant (CFA)-induced inflammation or with an intraplantar injection of NGF. Although CFA injection results in the up-regulation of calcitonin gene-related peptide (CGRP) levels in the primary sensory neurons, blocking p75(NTR) abolishes this effect. We further demonstrate that pro-NGF is the predominant ligand of p75(NTR) in vivo. Plasmin treatment, which is intended to decompose pro-NGF, ameliorates CFA-induced hyperalgesia. In addition, an intraplantar injection of pro-NGF induces hyperalgesia. These data together suggest that pro-NGF, as well as mature NGF, binding to p75(NTR) plays an important role in inflammation-induced hyperalgesia. Interference in the binding may provide a therapeutic approach for the treatment of inflammatory pain.

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Citations

Jun 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Ai SugiuraKazuhisa Takahashi
Jul 9, 2013·Molecular Neurobiology·Damien P Kuffler
Mar 10, 2011·Molecular Pain·Ricardo KusudaGuilherme Lucas
Nov 26, 2009·Neuroscience·L F FerrariJ D Levine
Oct 14, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yu FukuiKazuhisa Takahashi
Feb 6, 2014·The European Journal of Neuroscience·Simona Capsoni
Feb 6, 2014·The European Journal of Neuroscience·Gary R Lewin, Anders Nykjaer
Dec 1, 2009·Biochemical and Biophysical Research Communications·Sonia CovaceuszachAntonino Cattaneo
May 15, 2020·The Prostate·Zhiqiang LiuPraveen Thumbikat
Apr 26, 2017·Annual Review of Neuroscience·Franziska DenkStephen B McMahon

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