Abstract
Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through the actions of inflammatory mediators, and one of the key molecules is nerve growth factor (NGF). Here we report that the administration of neutralizing antibody to the neurotrophin receptor p75 (p75(NTR)) blocks hyperalgesia, which develops with complete Freund's adjuvant (CFA)-induced inflammation or with an intraplantar injection of NGF. Although CFA injection results in the up-regulation of calcitonin gene-related peptide (CGRP) levels in the primary sensory neurons, blocking p75(NTR) abolishes this effect. We further demonstrate that pro-NGF is the predominant ligand of p75(NTR) in vivo. Plasmin treatment, which is intended to decompose pro-NGF, ameliorates CFA-induced hyperalgesia. In addition, an intraplantar injection of pro-NGF induces hyperalgesia. These data together suggest that pro-NGF, as well as mature NGF, binding to p75(NTR) plays an important role in inflammation-induced hyperalgesia. Interference in the binding may provide a therapeutic approach for the treatment of inflammatory pain.
References
May 29, 1992·Cell·K F LeeR Jaenisch
Mar 1, 1992·Arthritis and Rheumatism·L AloeR Levi-Montalcini
Mar 31, 1986·FEBS Letters·N MazurekU Otten
Jan 26, 1989·Nature·R M Lindsay, A J Harmar
Aug 1, 1988·Brain Research·K NoguchiM Tohyama
Dec 15, 1983·Nature·C J Woolf
Sep 1, 1994·Neuroscience·C J WoolfJ Winter
Aug 1, 1995·Nature Medicine·S B McMahonD L Shelton
Dec 1, 1994·The European Journal of Neuroscience·G R LewinL M Mendell
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·E S AntonW D Matthew
Oct 1, 1995·Pain· Andreev NYuS B McMahon
Aug 30, 1996·The Journal of Biological Chemistry·A Blöchl, C Sirrenberg
Aug 1, 1996·Pain·A RueffL M Mendell
Jun 1, 1997·British Journal of Pharmacology·C J WoolfS Poole
Aug 15, 1997·The EMBO Journal·E LiepinshC F Ibáñez
Dec 3, 1998·Neuroscience Letters·I BergmannM Koltzenburg
Jan 20, 1999·The British Journal of Dermatology·H A BullP M Dowd
Dec 14, 1999·Neuron·T YamashitaY A Barde
Jun 10, 2000·Science·C J Woolf, M W Salter
Sep 6, 2000·Brain Research·M J SammonsS Bingham
Feb 13, 2001·Pain·S PezetB Calvino
Jun 22, 2001·Nature·H H ChuangD Julius
Aug 25, 2001·Molecular and Cellular Neurosciences·M FahnestockM D Coughlin
Dec 1, 2001·Science·R LeeB L Hempstead
Dec 12, 2001·Neuron·F D Miller, D R Kaplan
Oct 9, 2002·Neuron·Ru-Rong JiClifford J Woolf
Nov 1, 2002·Neuron·Michael S BeattieSung Ok Yoon
Nov 9, 2002·Science·Jose M CosgayaEric M Shooter
Aug 20, 2003·Neuron·Olayinka A DinaJon D Levine
Mar 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·A W HarringtonK M Giehl
Feb 22, 2005·Current Opinion in Neurobiology·Anders NykjaerClaus Munck Petersen
Citations
Jun 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Ai SugiuraKazuhisa Takahashi
Jul 9, 2013·Molecular Neurobiology·Damien P Kuffler
Mar 10, 2011·Reproductive Biology and Endocrinology : RB&E·Yan LiLei Bao
Mar 10, 2011·Molecular Pain·Ricardo KusudaGuilherme Lucas
Mar 10, 2011·PloS One·Simona CapsoniAntonino Cattaneo
Jan 12, 2010·The Journal of Hand Surgery·Nahoko IwakuraKazuki Kuniyoshi
Nov 26, 2009·Neuroscience·L F FerrariJ D Levine
Apr 8, 2015·The Journal of Investigative Dermatology·Barthold N SchüttenhelmJan C Holstege
Oct 14, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yu FukuiKazuhisa Takahashi
Feb 6, 2014·The European Journal of Neuroscience·Simona Capsoni
Feb 6, 2014·The European Journal of Neuroscience·Gary R Lewin, Anders Nykjaer
Oct 8, 2013·Neuroscience·A KhodorovaG Strichartz
Jun 29, 2015·Archives of Oral Biology·Yu-Wei WuXu-Chen Ma
Dec 1, 2009·Biochemical and Biophysical Research Communications·Sonia CovaceuszachAntonino Cattaneo
Mar 31, 2010·Pain·Kay E McNameeJulia J Inglis
Oct 26, 2016·Journal of Medicinal Chemistry·Bryan H Norman, Jeff S McDermott
Nov 9, 2016·Neuroscience·Alla KhodorovaGary Strichartz
Jun 13, 2014·Spine·Sonia KarthaBeth A Winkelstein
Apr 11, 2017·Pain·Douglas M LopesStephen B McMahon
Jan 18, 2013·Spine·Yusuke MatsuuraKazuhisa Takahashi
May 15, 2020·The Prostate·Zhiqiang LiuPraveen Thumbikat
May 9, 2014·Operative Dentistry·A M ShadeK S Vandewalle
Feb 24, 2019·Arthritis Research & Therapy·Anna KatriKim Henriksen
Apr 26, 2017·Annual Review of Neuroscience·Franziska DenkStephen B McMahon
Nov 6, 2020·Nature Communications·Vartika MishraSerge Przedborski
Jan 23, 2021·European Journal of Pharmacology·Junya SugimotoShizuko Muraoka