The Pan-Omics Landscape of Renal Cell Carcinoma and Its Implication on Future Clinical Practice

Kidney Cancer
Jennifer J Huang, James J Hsieh

Abstract

Renal cell carcinoma has traditionally been classified based on histological features. Contemporary studies have identified genomic, transcriptomic, epigenomic, and metabolomic signatures that correspond to or even transcend histological subtypes. Much remains to be learned about improving the algorithm of pan-omics integration for precision oncology, which will not only advance our understanding of RCC pathobiology and treatment response but also result in novel therapeutic opportunities. Accordingly, this review focuses on recent RCC multi-omics literature. Encouragingly, a few reports on omics integration into routinely employed prognostic risk models have shown early promise that could lay the foundation for future development of precision kidney cancer therapies. Hence, this article serves as a primer on what we have learned and how we might better realize the clinical potential of the burgeoning pan-omics data.

References

Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·D GloverS Vogl
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FyfeA C Louie
Mar 20, 2002·Cytokine & Growth Factor Reviews·Filippo BelardelliJohn M Kirkwood
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William G Kaelin
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J MotzerMadhu Mazumdar
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tarek M MekhailRonald Bukowski
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Houston ThompsonEugene D Kwon
Jun 1, 2007·The New England Journal of Medicine·Gary HudesUNKNOWN Global ARCC Trial
Oct 17, 2008·Nature Reviews. Cancer·William G Kaelin
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierRonald M Bukowski
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerRobert A Figlin
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 7, 2011·Therapy·Chiara Battelli, Daniel C Cho
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Apr 21, 2012·Current Cancer Drug Targets·Z MihalyB Gyorffy
Jun 25, 2013·Nature·UNKNOWN Cancer Genome Atlas Research Network
Dec 4, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E HutsonRobert J Motzer
Mar 13, 2014·European Urology·Samira A BrooksW Kimryn Rathmell
Jun 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A Rosenberg
Aug 27, 2014·Cancer Cell·Caleb F DavisChad J Creighton
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toni K ChoueiriRobert J Motzer
Mar 8, 2016·Cell Reports·Fengju ChenChad J Creighton
Aug 3, 2016·The Journal of Clinical Investigation·Jianing XuJames J Hsieh
Jan 26, 2017·The New England Journal of Medicine·Toni K Choueiri, Robert J Motzer
Mar 10, 2017·Nature Reviews. Disease Primers·James J HsiehVincenzo Ficarra
Mar 23, 2017·Cell Reports·Amrita M NargundJames J Hsieh
May 23, 2017·Cancer Cell·Yiqun ZhangChad J Creighton
Jun 15, 2017·JCI Insight·Jozefina CasuscelliJames J Hsieh
Aug 5, 2017·Nature Communications·Fengju ChenChad J Creighton
Sep 28, 2017·European Urology Focus·Jozefina CasuscelliAbraham Ari Hakimi
Apr 5, 2018·Cell Reports·Christopher J RickettsW Marston Linehan
Apr 17, 2018·Cell·Thomas J MitchellUNKNOWN TRACERx Renal Consortium
Apr 17, 2018·Cell·Samra TurajlicUNKNOWN TRACERx Renal Consortium
Aug 18, 2018·Cancer Discovery·Spencer C WeiJames P Allison

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.