PMID: 9428341Jan 15, 1998Paper

The paradox of neoplastic glial cell invasion of the brain and apparent metastatic failure

Anticancer Research
G J Pilkington

Abstract

Brain tumours fall into 3 major categories: a) secondary tumours which have originated in distant parts of the body, b) meningiomas, which generally grow on, rather than in, the substance of the brain and c) intrinsic tumours which are generally composed of neoplastic glial cells. Secondary tumours show a marked propensity for metastasis to, and growth in, the brain; up to 24% of cancers are thought to metastasize to the brain. These metastatic deposits are frequently multiple but are usually well circumscribed lesions. Meningiomas are usually benign lesions which grow by expansion and seeding along the leptomeninges on the surface of the brain. Such tumours may, however, recur and show some degree of invasion of the underlying cerebral cortex. The most common form of brain tumour is the glioma, of which there are various histological types. These tumours generally fail to metastasize out of the nervous system. Two plausable explanations for this failure have been recently proposed. Firstly, the vascular basal laminae of the brain appears to exclude intravasation of neoplastic glia and secondly, if such cells do enter the vascular system they are prevented from binding to the endothelial cells of "target" organs by virtue of a ...Continue Reading

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