DOI: 10.1101/498212Dec 16, 2018Paper

The paradox of Rapid Eye Movement sleep in the light of oscillatory activity and functional synchronization during phasic and tonic microstates

BioRxiv : the Preprint Server for Biology
Péter SimorIlona Kovács


Rapid Eye Movement (REM) sleep is a peculiar neural state showing a combination of muscle atonia and intense cortical activity. REM sleep is usually considered as a unitary state in neuroscientific research; however, it is composed of two different microstates: phasic and tonic REM. These differ in awakening thresholds, sensory processing, and cortical oscillations. Nevertheless, studies examining cortical oscillations during REM microstates are scarce, and used low spatial sampling. Here, we analyzed the data of 18 healthy individuals assessed by high-density sleep EEG recordings. We systematically contrasted phasic and tonic REM periods in terms of topographical distribution, source localization, as well as local, global and long-range synchronization of frequency-specific cortical activity. Tonic periods showed relatively increased high alpha and beta power over frontocentral derivations. In addition, higher frequency components of beta power exhibited increased global synchronization during tonic compared to phasic states. In contrast, in phasic periods we found increased power and synchronization of low frequency oscillations coexisting with increased and synchronized gamma activity. Source localization revealed several mu...Continue Reading

Related Concepts

Cerebral Cortex
Rapid Eye Movement
Sleep, REM
Spatial Distribution
Epilepsy, Tonic
Sleep Electroencephalogram
Lateral to the Right
Congenital Spastic Cerebral Palsy

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