Abstract
Low dose total body irradiation (TBI) administered in small fractional doses (5-10 cGy) for the treatment of disseminated malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma can be extremely toxic with substantial bone marrow depression. We elected to study bone marrow suppression following fractionated TBI in the rabbit. New Zealand white/female rabbits were thus treated with one of the following three schedules: (1) 3 fractions of 10 cGy per week; (2) 5 fractions of 10 cGy per week; and (3) 5 fractions of 25 cGy per week. Total doses ranged from 1050 to 2625 cGy and animals were sacrificed immediately, 4 weeks, or 8 weeks following completion of therapy. With the 10 cGy/day schedules, slight depression of total WBC counts and lymphocyte numbers occurred during and to the completion of irradiation followed by a rebound to greater than normal levels. With the 25 cGy schedule, a significant WBC and lymphocyte depression occurred at an accumulated dose of 1000 cGy and continued to decrease up to 2500 cGy, followed again by a rebound to greater than normal levels. The depression with the 25 cGy fractions was significantly greater than with the 10 cGy daily fractions. Thus, the severe and persistent p...Continue Reading
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