PMID: 6396745Oct 1, 1984Paper

The paradoxes in patterns and mechanism of bone marrow regeneration after irradiation. 2. Total body irradiation

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
P RubinC W Scarantino

Abstract

Low dose total body irradiation (TBI) administered in small fractional doses (5-10 cGy) for the treatment of disseminated malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma can be extremely toxic with substantial bone marrow depression. We elected to study bone marrow suppression following fractionated TBI in the rabbit. New Zealand white/female rabbits were thus treated with one of the following three schedules: (1) 3 fractions of 10 cGy per week; (2) 5 fractions of 10 cGy per week; and (3) 5 fractions of 25 cGy per week. Total doses ranged from 1050 to 2625 cGy and animals were sacrificed immediately, 4 weeks, or 8 weeks following completion of therapy. With the 10 cGy/day schedules, slight depression of total WBC counts and lymphocyte numbers occurred during and to the completion of irradiation followed by a rebound to greater than normal levels. With the 25 cGy schedule, a significant WBC and lymphocyte depression occurred at an accumulated dose of 1000 cGy and continued to decrease up to 2500 cGy, followed again by a rebound to greater than normal levels. The depression with the 25 cGy fractions was significantly greater than with the 10 cGy daily fractions. Thus, the severe and persistent p...Continue Reading

References

Aug 1, 1978·Cancer·T L Thar, R R Million
Apr 17, 1975·The New England Journal of Medicine·E ThomasC D Buckner
Apr 24, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Sep 1, 1978·International Journal of Radiation Oncology, Biology, Physics·J P DrozM Tubiana
Feb 1, 1979·International Journal of Radiation Oncology, Biology, Physics·R E Johnson
Mar 1, 1976·International Journal of Radiation Oncology, Biology, Physics·J T ChaffeyS Hellman
Mar 1, 1976·International Journal of Radiation Oncology, Biology, Physics·R E Johnson, U Rühl
Mar 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J A Del Regato
Jan 1, 1970·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H CroizatM Tubiana
Oct 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C W ScarantinoL S Constine

❮ Previous
Next ❯

Citations

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P MauchH J Deeg
Aug 1, 1996·International Journal of Radiation Oncology, Biology, Physics·C W ScarantinoJ Delrowe
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James O ArmitageStewart Kroll
Jan 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R GalliniN G Testa
Jan 1, 1986·Scandinavian Journal of Haematology. Supplementum·B FrischS Chaichik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.